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Books > Medicine > Clinical & internal medicine > Diseases & disorders
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Cancer - Blueprint of a Tumor (Hardcover)
Loot Price: R1,619
Discovery Miles 16 190
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Cancer - Blueprint of a Tumor (Hardcover)
Series: Colloquium Series on The Genetic Basis of Human Disease
Expected to ship within 10 - 15 working days
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Scientists are deciphering the biology of the tumor cell at a level
of detail that would have been hard to imagine just a decade or so
ago. The development of high-throughput DNA sequencing and genomics
technologies have allowed an understanding of the development,
growth, survival, and spread of cancer cells in the body. From this
information, we now have a basic blueprint or roadmap of how a
single damaged cell can develop into a pre-malignant lesion, a
primary tumor, and finally, a lethal tumor that may spread
throughout the body and resist both medical therapy and host immune
responses. In this book, we provide an overview of our current
understanding of this cancer blueprint, which has been aided both
by the study of familial cancer syndromes, in vitro studies of
cancer cells, and animal models. Three classes of genes have
emerged from these studies: tumor suppressor genes needed for
normal growth control and DNA repair; oncogenes that regulate cell
growth and survival, and epigenetic modifiers, enzymes that
regulate the modification of DNA and the proteins that form
chromatin. Each of these three classes of genes is mutated or
altered at least once in virtually all malignant cancer cells.
Current technologies permit the DNA sequencing of cancer exomes
(coding gene sequencing), whole genomes, transcriptome (all
expressed genes), and DNA methylation profiling. These studies show
that all tumors have unique constellations of mutated, rearranged,
amplified, and deleted genes. Single-cell sequencing further shows
that there is extensive variation in individual cells in the tumor;
that cancers evolve, and have many of the properties of a
multi-cellular entity. Lastly, cancer cells, through mutations in
epigenetic modifiers, can reprogram the genome and unlock entire
developmental and gene expression pathways to adapt and survive in
changing conditions. This reprogramming allows the tumor to elude
the host body's defenses, radiotherapy, chemotherapy, and targeted
therapy that we use in cancer treatment. Understanding this cancer
blueprint paves the way for the development of future therapies to
treat and eliminate cancer.
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