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This volume includes contributions by the leading experts in the
field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and
other fungal organisms provide models for aging research that are
relevant to organismic aging and to the aging processes occurring
in the human body. Replicative aging, in which only the mother cell
ages while the daughter cell resets the clock to zero is a model
for the aging of stem cell populations in humans, while
chronological aging (measured by survival in stationary phase) is a
model for the aging processes in postmitotic cells (for instance,
neurons of the brain). Most mechanisms of aging are studied in
yeast. Among them, this book discusses: mitochondrial theories of
aging, emphasizing oxidative stress and retrograde responses; the
role of autophagy and mitophagy; the relationship of apoptosis to
aging processes; the role of asymmetric segregation of damage in
replicative aging; the role of replication stress; and the role of
the cytoskeleton in aging. Modern methods of yeast genetics and
genomics are described that can be used to search for
aging-specific functions in a genome-wide unbiased fashion. The
similarities in the pathology of senescence (studied in yeast) and
of cancer cells, including genome instability, are examined.
This volume includes contributions by the leading experts in the
field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and
other fungal organisms provide models for aging research that are
relevant to organismic aging and to the aging processes occurring
in the human body. Replicative aging, in which only the mother cell
ages while the daughter cell resets the clock to zero is a model
for the aging of stem cell populations in humans, while
chronological aging (measured by survival in stationary phase) is a
model for the aging processes in postmitotic cells (for instance,
neurons of the brain). Most mechanisms of aging are studied in
yeast. Among them, this book discusses: mitochondrial theories of
aging, emphasizing oxidative stress and retrograde responses; the
role of autophagy and mitophagy; the relationship of apoptosis to
aging processes; the role of asymmetric segregation of damage in
replicative aging; the role of replication stress; and the role of
the cytoskeleton in aging. Modern methods of yeast genetics and
genomics are described that can be used to search for
aging-specific functions in a genome-wide unbiased fashion. The
similarities in the pathology of senescence (studied in yeast) and
of cancer cells, including genome instability, are examined.
The word stress is everywhere and highly overused. Everyone is
stressed, it seems, all the time. Looking into the meaning of
stress in the natural science and the humanities, this book
explores cellular stress as cause of and in correlation with what
humans experience as stress. When do we psychologically feel stress
and when do we show physiological evidence of stress in our brain?
Stress is a deviation from what feels normal and healthy. It can be
created by social or economic factors and become chronic, which has
substantial impacts on the individual and society as a whole.
Focusing on poverty as one chronic inducer of stress, this book
explores how the lack of pressure-free time, the hardships and
unpredictability of everyday life and a general lack of protection
lead to destructive toxic stress. This pressure affects cognitive
and social functioning, brain development during childhood and may
also result in premature aging. How can the sciences inform our
understanding of and our response to stress? What can be done about
toxic stress both on a personal level and in terms of structures
and policies? The book is written for anyone interested in stress,
its causes and consequences, and its relationship to poverty.
The word stress is everywhere and highly overused. Everyone is
stressed, it seems, all the time. Looking into the meaning of
stress in the natural science and the humanities, this book
explores cellular stress as cause of and in correlation with what
humans experience as stress. When do we psychologically feel stress
and when do we show physiological evidence of stress in our brain?
Stress is a deviation from what feels normal and healthy. It can be
created by social or economic factors and become chronic, which has
substantial impacts on the individual and society as a whole.
Focusing on poverty as one chronic inducer of stress, this book
explores how the lack of pressure-free time, the hardships and
unpredictability of everyday life and a general lack of protection
lead to destructive toxic stress. This pressure affects cognitive
and social functioning, brain development during childhood and may
also result in premature aging. How can the sciences inform our
understanding of and our response to stress? What can be done about
toxic stress both on a personal level and in terms of structures
and policies? The book is written for anyone interested in stress,
its causes and consequences, and its relationship to poverty.
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