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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical)
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Aging Research in Yeast (Hardcover, 2012)
Loot Price: R4,631
Discovery Miles 46 310
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Aging Research in Yeast (Hardcover, 2012)
Series: Subcellular Biochemistry, 57
Expected to ship within 10 - 15 working days
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This volume includes contributions by the leading experts in the
field of yeast aging. Budding yeast (Saccharomyces cerevisiae) and
other fungal organisms provide models for aging research that are
relevant to organismic aging and to the aging processes occurring
in the human body. Replicative aging, in which only the mother cell
ages while the daughter cell resets the clock to zero is a model
for the aging of stem cell populations in humans, while
chronological aging (measured by survival in stationary phase) is a
model for the aging processes in postmitotic cells (for instance,
neurons of the brain). Most mechanisms of aging are studied in
yeast. Among them, this book discusses: mitochondrial theories of
aging, emphasizing oxidative stress and retrograde responses; the
role of autophagy and mitophagy; the relationship of apoptosis to
aging processes; the role of asymmetric segregation of damage in
replicative aging; the role of replication stress; and the role of
the cytoskeleton in aging. Modern methods of yeast genetics and
genomics are described that can be used to search for
aging-specific functions in a genome-wide unbiased fashion. The
similarities in the pathology of senescence (studied in yeast) and
of cancer cells, including genome instability, are examined.
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