Proceedings of the Sixth International Conference on Kindling, featuring valuable summaries of the participants current cutting-edge research on the kindling of seizures and related phenomena in epilepsy.

The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

Proceedings of the Sixth International Conference on Kindling, featuring valuable summaries of the participants current cutting-edge research on the kindling of seizures and related phenomena in epilepsy.

Keynote Adress. Genetic Predisposition and Kindling Susceptibility in Primates; J.A. Wada. Developmental Patterns. Idiosyncrasies of Limbic Kindling in Developing Rats; K.Z. Haas, et al. Long-Term Effects of Kindling on Learning and Memory in the Developing Brain; M. Sarkisian, et al. Electrophysiological Mechanisms. Long-Lasting Prolongation of NMDA Channel Openings after Kindling; I. Mody, D.N. Lieberman. Morphological and Anatomical Mechanisms. Role of Rhinencephalic Networks in Early Stage Kindling; J.L. Burchfiel. Synaptic Pharmacology and Neurochemistry of Kindling. Regionally Specific Changes in Glatamate and GABAA Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat; F.H. Lopes da Silva, et al. Behavioral Effects of Kindling. Amygdala Kindling and Rodent Anxiety; R. Adamec. Drugs and Kindling. Protective Effect of Brain-Derived Neurotrophic Factor in Hippocampal Kindling; S. Reybiel. Clinical Implications of Kindling. The Syndrome of Mesial Temporal Lobe Epilepsy: A Role for Kindling; J. Engel. 27 additional articles. Index.