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This issue of Recent Results in Cancer Research presents a
comprehensive review of current understanding of chromosomal
instability in cancer and of strategies to use this information for
better treatment of patients with cancer. Cancer is a disease of
the chromosomes, and chromosomal instability in cancer disrupts
gene function by either inactivating tumor suppressor genes or
activating growth-promoting oncogenes. The chromosomal basis for
these aberrations is either translocations, which change the
integrity of genes, or abnormal numbers of chromosomes, a condition
referred to as aneuploidy, which results in abnormal gene
expression levels. Such structural or numerical chromosomal
aberrations are specific for distinct tumor entities. The degree of
chromosomal instability and the degree of intratumor heterogeneity
have profound consequences for disease outcome and for therapeutic
stratification.
This issue of Recent Results in Cancer Research presents a
comprehensive review of current understanding of chromosomal
instability in cancer and of strategies to use this information for
better treatment of patients with cancer. Cancer is a disease of
the chromosomes, and chromosomal instability in cancer disrupts
gene function by either inactivating tumor suppressor genes or
activating growth-promoting oncogenes. The chromosomal basis for
these aberrations is either translocations, which change the
integrity of genes, or abnormal numbers of chromosomes, a condition
referred to as aneuploidy, which results in abnormal gene
expression levels. Such structural or numerical chromosomal
aberrations are specific for distinct tumor entities. The degree of
chromosomal instability and the degree of intratumor heterogeneity
have profound consequences for disease outcome and for therapeutic
stratification.
Behandlung von Patienten mit inkurablen Tumorerkrankungen im
multiprofessionellen Team Kriterien fur individuelle,
patientenorientierte Therapieentscheidungen Symptom- und
organbezogene Empfehlungen zum operativen und interventionellen
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