Chromosomal Instability in Cancer Cells (Paperback, Softcover reprint of the original 1st ed. 2015)

This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Recent Results in Cancer Research, 200
Release date:	October 2016
First published:	2015
Editors:	B Michael Ghadimi • Thomas Ried
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	224
Edition:	Softcover reprint of the original 1st ed. 2015
ISBN-13:	978-3-319-34962-6
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	3-319-34962-7
Barcode:	9783319349626

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