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Molecular Diagnostics in Dermatology and Dermatopathology
presents the basics of molecular biology and molecular diagnostic
methods most commonly used in the clinical laboratory, with an
emphasis on the concepts and testing most relevant to
dermatological diseases. Topics include the integration of newer
diagnostic and prognostic techniques with traditional histologic
approaches, and discussions of regulatory, ethical, legal, economic
issues and newer technologies. This important diagnostic tool
outlines the clinically relevant uses (i.e.; diagnostic, staging
and/or prognostic) applications of these techniques in the field of
dermatology. Molecular studies that investigate the pathogenesis of
skin diseases will be excluded, unless they also have a direct
diagnostic utility. The book will be of interest to practicing
pathologists, dermatology and pathology residents, dermatologists,
and dermatopathologists."
This book describes both the technologies used in the discovery of
melanoma biomarkers and the clinical application of these
biomarkers for diagnosis and staging of disease, determination of
prognosis, treatment planning, monitoring of response to therapy,
identification of novel therapeutic targets and drug development. A
broad range of biomarkers (DNA/chromosomal, mRNA, microRNA,
mitochondrial DNA, epigenetic and protein) is outlined. As
therapies for melanoma become increasingly more target specific,
the identification, validation and use of biomarkers will
invariably play a greater role in the management of patients with
this disease. Diagnostic and Prognostic Biomarkers and Therapeutic
Targets in Melanoma is an essential resource for oncologists,
dermatologists, dermatopathologists, general pathologists with an
interest in melanoma, and melanoma researchers.
Molecular Diagnostics in Dermatology and Dermatopathology presents
the basics of molecular biology and molecular diagnostic methods
most commonly used in the clinical laboratory, with an emphasis on
the concepts and testing most relevant to dermatological diseases.
Topics include the integration of newer diagnostic and prognostic
techniques with 'traditional' histologic approaches, and
discussions of regulatory, ethical, legal, economic issues and
'newer' technologies. This important diagnostic tool outlines the
clinically relevant uses (i.e.; diagnostic, staging and/or
prognostic) applications of these techniques in the field of
dermatology. Molecular studies that investigate the pathogenesis of
skin diseases will be excluded, unless they also have a direct
diagnostic utility. The book will be of interest to practicing
pathologists, dermatology and pathology residents, dermatologists,
and dermatopathologists.
This book describes both the technologies used in the discovery of
melanoma biomarkers and the clinical application of these
biomarkers for diagnosis and staging of disease, determination of
prognosis, treatment planning, monitoring of response to therapy,
identification of novel therapeutic targets and drug development. A
broad range of biomarkers (DNA/chromosomal, mRNA, microRNA,
mitochondrial DNA, epigenetic and protein) is outlined. As
therapies for melanoma become increasingly more target specific,
the identification, validation and use of biomarkers will
invariably play a greater role in the management of patients with
this disease. Diagnostic and Prognostic Biomarkers and Therapeutic
Targets in Melanoma is an essential resource for oncologists,
dermatologists, dermatopathologists, general pathologists with an
interest in melanoma, and melanoma researchers.
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