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The Genetics of Cancer (Hardcover): B.A.J. Ponder, Michael J. Waring The Genetics of Cancer (Hardcover)
B.A.J. Ponder, Michael J. Waring
R3,137 Discovery Miles 31 370 Ships in 10 - 15 working days

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in this work illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Cancer II (Hardcover, 1st ed. 2018): Michael J. Waring Cancer II (Hardcover, 1st ed. 2018)
Michael J. Waring
R7,631 Discovery Miles 76 310 Ships in 10 - 15 working days

This book reviews recent breakthroughs in anti-cancer drug discovery. Building on the previous volume in the series, it outlines some of the most significant developments that have occurred in the field in the subsequent period that have led to new drug approvals or promising clinical candidates. The volume is divided into chapters that each relate to a specific protein or protein class. Each chapter provides an overview of the underlying biology and then emphasises the medicinal chemistry strategies and tactics that led to the most significant drugs and drug candidates. A summary of clinical data and the future outlook for the field is also provided. Each chapter is authored by experts in the topic and who have themselves made significant contributions to their respective fields.

DNA Binders and Related Subjects (Hardcover, 2005 ed.): Michael J. Waring, Jonathan B. Chaires DNA Binders and Related Subjects (Hardcover, 2005 ed.)
Michael J. Waring, Jonathan B. Chaires
R5,587 Discovery Miles 55 870 Ships in 10 - 15 working days
Internet Information Server (IIS) 6.0 Fundamentals - A Guide to Understanding and Implementing IIS 6.0 on Windows (Paperback):... Internet Information Server (IIS) 6.0 Fundamentals - A Guide to Understanding and Implementing IIS 6.0 on Windows (Paperback)
Michael J Ware
R532 Discovery Miles 5 320 Ships in 10 - 15 working days

This book demonstrates the advances offered by Microsoft's latest version of Internet Information Server (IIS). A thorough reading will reveal how to get up and running with IIS 6.0, Network Load Balancing Services (NLBS), as well as Microsoft's Application Center on Windows Server 2003. Additionally, Microsoft's implementation of FTP SMTP, and NNTP functionality will be explained. In This Book You'll Learn: How to install and setup IIS 6.0 How to configure web site application pools How to address common security issues How to configure Network Load Balancing Service About Windows Server 2003 advances About MS Application Center 2000. How to configure FTP, SMTP, NNTP and much more

DNA-targeting Molecules as Therapeutic Agents (Hardcover): Michael J. Waring DNA-targeting Molecules as Therapeutic Agents (Hardcover)
Michael J. Waring
R5,596 Discovery Miles 55 960 Ships in 10 - 15 working days

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies. The editor and contributing authors are leaders in their fields and provide useful perspectives from diverse and interdisciplinary backgrounds on the current status of this broad area. The role played by chemistry is a unifying theme. Early chapters cover methodologies to evaluate DNA-interactive agents and then the book provides examples of DNA-interactive molecules and technologies in development as therapeutic agents. DNA-binding metal complexes, peptide and polyamide–DNA interactions, and gene targeting tools are some of the most compelling topics treated in depth. This book will be a valuable resource for postgraduate students and researchers in chemical biology, biochemistry, structural biology and medicinal fields. It will also be of interest to supramolecular chemists and biophysicists.

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