It has been recognized for almost 200 years that certain families
seem to inherit cancer. It is only in the past decade, however,
that molecular genetics and epidemiology have combined to define
the role of inheritance in cancer more clearly, and to identify
some of the genes involved. The causative genes can be tracked
through cancer-prone families via genetic linkage and positional
cloning. Several of the genes discovered have subsequently been
proved to play critical roles in normal growth and development.
There are also implications for the families themselves in terms of
genetic testing with its attendant dilemmas, if it is not clear
that useful action will result. The chapters in this work
illustrate what has already been achieved and take a critical look
at the future directions of this research and its potential
clinical applications.
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