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The spectrum of available treatment options for benign prostatic
hyperplasia (BPH) is matched by the spectrum of disease severity,
and with up to 90 per cent of men in their 80s suffering from BPH
to some extent, it is imperative that patients are offered the full
range of options to manage the disease. Pharmacologic therapies
available for the treatment of lower urinary tract symptoms
secondary to BPH include alpha-adrenoceptor antagonists, such as
terazosin, doxazosin, alfuzosin and tamsulosin, and the
5-alpha-reductase inhibitors, finasteride and dutasteride. Other
strategies, such as plant-derived medication or watchful waiting,
are applied to varying extents. Derived from the benchmark title on
BPH - the Textbook of Benign Prostatic Hyperplasia, 2nd edition -
this well written and highly illustrated guide covers all these
therapies and presents physicians with all they need to know to
successfully manage the disease.
Erectile dysfunction (ED) affects 20-30 million American men, most
of whom are over 50 years of age. In a UK-based study, 32% of
British men had difficulty obtaining an erection, 20% with
maintaining an erection. In recent years the physiology and
pathophysiology of ED have changed our understanding of what ED is
from a purely psychological-based disorder to a multifactorial one,
with neurological, endocrinological, psychological factors and the
role of the vascular system. Recently identified risk factors
include diabetes, cardiovascular disease, spinal cord injury,
smoking, depression, atherosclerosis, hypertension, pelvic surgery
and trauma, pharmacological medications, arthritis, peripheral
vascular disease, substance abuse, endocrine abnormalities and
peptic ulcer disease. Many ED patients have a combination of these
risk factors, thus exacerbating ED further. The treatment of ED was
revolutionized in 1998 with the introduction of sildenafil. Beside
these oral treatments, newer injectable agents are being
investigated as are topical preparations. However, not all patients
are tolerant of oral agents, many patients still require penile
reconstruction with penile implants, an option with low
complications and morbidity. There are options for all patients and
this excellent, updated text, edited by some of the world's leading
authorities - Culley Carson, Roger Kirby and Irwin Goldstein -
discusses them all.
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