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One of the greatest public health achievements during the 20th century was the dramatic reduction in the incidence of infectious diseases due to the development of improved hygiene, vaccines, and antimicrobial agents. However, new infectious diseases are emerging and bacteria-induced illnesses - such as tuberculosis, whooping cough, and typhoid fever - are still a major cause of global mortality. In recent decades, the development of molecular biology and genetic tools has led to extensive studies on the molecular and cellular aspects of the virulence properties of pathogenic bacteria. In this book, a group of distinguished scientists from eight different countries and three continents, under the expert guidance of the editors Camille Locht and Michel Simonet, overview the molecular and cellular mechanisms of bacterial pathogenesis. The 15 chapters are organized into five sections: a) approaches to the study of bacterial pathogenesis; b) bacterial adhesion to the cell surface and extracellular matrix of host tissues; c) poisoning the host by toxins; d) cellular invasion by bacterial pathogens; and e) bacterial evasion of host defenses. The book comprehensively describe the most relevant and up-to-date information on pathogenic features across the bacterial world. Aimed at the entire scientific community from students to senior scientists and physicians, Bacterial Pathogenesis is relevant to a broad range of people interested in the mechanisms of bacterial infectious diseases and is a recommended text for all microbiology laboratories.
"Whistleblowing" steht im letzten Jahrzehnt vermehrt als Schlagwort fur den Streit um die rechtliche Einordnung von Arbeitnehmeranzeigen im deutschen und internationalen Arbeitsrecht. In den USA grundsatzlich positiv bewertet, wird Whistleblowing in Deutschland oftmals vorschnell als "verpfeifen" verkannt, ohne dass dabei auf die unterschiedlichen Erscheinungsformen eingegangen wird. Die Arbeit zeigt die positiven und negativen Eigenschaften des externen und internen Whistleblowings aus der Sicht von Wirtschaftsunternehmen auf. Im Zuge der Untersuchung wird die deutsche Rechtssprechung und Fachliteratur analysiert und bewertet. Zudem zeigt der Autor auf, inwiefern Wirtschaftunternehmen in Deutschland ein internes Whistleblowingsystem rechtskonform und effektiv implementieren konnen.
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