The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected

Advanced Design Problems in Aerospace Engineering, Volume 1: Advanced Aerospace Systems presents six authoritative lectures on the use of mathematics in the conceptual design of various types of aircraft and spacecraft. It covers the following topics: design of rocket-powered orbital spacecraft (Miele/Mancuso), design of Moon missions (Miele/Mancuso), design of Mars missions (Miele/Wang), design of an experimental guidance system with a perspective flight path display (Sachs), neighboring vehicle design for a two-stage launch vehicle (Well), and controller design for a flexible aircraft (Hanel/Well). This is a reference book of interest to engineers and scientists working in aerospace engineering and related topics.

This book provides a detailed and comprehensive overview of the role of diagnostic imaging in the assessment and management of trauma and polytrauma in children. The coverage includes imaging of injuries to the head, thorax, abdomen, bone and musculoskeletal system, with careful attention to the newest imaging techniques, imaging during the course of recovery and imaging of complications. A series of illustrative cases underline the prognostic value of imaging. In addition, an individual chapter is devoted to diagnostic imaging in cases of child abuse. The book concludes by discussing informed consent and medicolegal issues related to the imaging of pediatric traumatic emergencies. "Imaging Trauma and Polytrauma in Pediatric Patients "will be invaluable in enabling radiologists and clinicians to identify the main features and signs of injuries on a wide range of imaging techniques, including X-ray, ultrasonography, computed tomography and magnetic resonance imaging.

This book contains the proceedings ofthe meeting on "Applied Mathematics in the Aerospace Field," held in Erice, Sicily, Italy from September 3 to September 10, 1991. The occasion of the meeting was the 12th Course of the School of Mathematics "Guido Stampacchia," directed by Professor Franco Giannessi of the University of Pisa. The school is affiliated with the International Center for Scientific Culture "Ettore Majorana," which is directed by Professor Antonino Zichichi of the University of Bologna. The objective of the course was to give a perspective on the state-of the-art and research trends concerning the application of mathematics to aerospace science and engineering. The course was structured with invited lectures and seminars concerning fundamental aspects of differential equa tions, mathematical programming, optimal control, numerical methods, per turbation methods, and variational methods occurring in flight mechanics, astrodynamics, guidance, control, aircraft design, fluid mechanics, rarefied gas dynamics, and solid mechanics. The book includes 20 chapters by 23 contributors from the United States, Germany, and Italy and is intended to be an important reference work on the application of mathematics to the aerospace field. It reflects the belief of the course directors that strong interaction between mathematics and engineering is beneficial, indeed essential, to progresses in both areas."

William Morris's interests were wide-ranging: he was a poet, writer, political and social activist, conservationist and businessman, as well as a brilliant and original designer and manufacturer. This book explores the balance between Morris's various spheres of activity and influence, places his art in the context of its time and explores his ongoing and far-reaching legacy. A pioneer of the Arts & Crafts Movement, William Morris (1834-1896) is one of the most influential designers of all time. Morris turned the tide of Victorian England against an increasingly industrialized manufacturing process towards a rediscovered respect for the skill of the maker. Morris's whole approach still resonates today, and his designs are popular and much admired. Published to mark the 125th anniversary of Morris's death, this book includes contributions from a wide range of Morris experts, with chapters on painting, church decoration and stained glass, interior decoration, furniture, tiles and tableware, wallpaper, textiles, calligraphy and publishing. Additional materials include a contextualized chronology of Morris's life and a list of public collections around the world where examples of Morris's work may be seen today. This study is a comprehensive, fully illustrated exploration of a great thinker and artist, and essential reading for anyone interested in the history of design. With 668 illustrations in colour

This book establishes an important mathematical connection between cooperative control problems and network optimization problems. It shows that many cooperative control problems can in fact be understood, under certain passivity assumptions, using a pair of static network optimization problems. Merging notions from passivity theory and network optimization, it describes a novel network optimization approach that can be applied to the synthesis of controllers for diffusively-coupled networks of passive (or passivity-short) dynamical systems. It also introduces a data-based, model-free approach for the synthesis of network controllers for multi-agent systems with passivity-short agents. Further, the book describes a method for monitoring link faults in multi-agent systems using passivity theory and graph connectivity. It reports on some practical case studies describing the effectivity of the developed approaches in vehicle networks. All in all, this book offers an extensive source of information and novel methods in the emerging field of multi-agent cooperative control, paving the way to future developments of autonomous systems for various application domains

The agricultural sector remains under increasing pressure to reduce its environmental impact and consequent contribution to climate change, whilst also producing enough food to feed a rapidly growing population. With the variety and volume of data, coupled with the advanced methods for data processing, a new era of digital agriculture is emerging as a possible solution to this monumental challenge. Smart farms: improving data-driven decision making in agriculture provides a comprehensive review of the recent advances in gathering and analysing data as a means of improving farm sustainability, productivity and profitability. The book discusses the evolution of farm information management systems, highlighting current trends and challenges, as well as methods of data acquisition and analysis, including the use of artificial intelligence.

Empires stretched around the world, but also made their presence felt in architecture and urban landscapes. The Architecture of Empire in Modern Europe traces the entanglement of the European built environment with overseas imperialism in the nineteenth and twentieth centuries. As part of imperial networks between metropole and colonies, in cities as diverse as Glasgow, Hamburg, or Paris, numerous new buildings were erected such as factories, mission houses, offices, and museums. These sites developed into the physical manifestations of imperial networks. As Europeans designed, used, and portrayed them, these buildings became meaningful imperial places that conveyed the power relations of empire and Eurocentric self-images. Engaging with recent debates about colonial history and heritage, this book combines a variety of sources, an interdisciplinary approach, and an international scope to produce a cultural history of European imperial architecture across borders.

Most people love cats. They're fluffy, playful, and can be a joy to have as a companion. However, they can also be huge assholes. So what can you do? How do you deal with a roommate who always seems to be plotting to kill you? While we all love sharing adorable photos of kittens, these frisky felines are known more for marching to the beat of their own drum than abiding by the rules. From running around your home at two in the morning, knocking everything off your shelves, or taking up most of your bed, these furry critters can be immensely selfish and disrespectful to those who give them endless love and affection. Why Cats Are Assholes is up for such a challenge. From studying their history all the way back to ancient Egypt, comedian Liz Miele-the daughter of veterinarians-digests the cat psyche to try and understand why they do the things they do, and how we, as their loyal servants, can handle domestic bliss with them around. With the help of her cat Pasta, Miele breaks down the common behaviors of cats in an attempt to try and better understand their plan of attack (if there is one), as well as what we can do to better prepare ourselves. Whether you have one, two, or twelve fur babies, Why Cats Are Assholes is the ultimate guide to better understanding your pet's behavior while taking back your home from these domesticated terrorists.

The conventional wisdom in contemporary social science claims that human races are not biologically valid categories. Many argue the very words 'race' and 'racial differences' should be abolished because they support racism. In Race, Vincent Sarich and Frank Miele challenge both these tenets. First, they cite the historical record, the art

In a series of provocative conversations with Skeptic magazine Ssenior editor Frank Miele, renowned University of California-Berkeley psychologist Arthur R. Jensen details the evolution of his thoughts on the nature of intelligence, tracing an intellectual odyssey that leads from the programs of the Great Society to the Bell Curve Wars and beyond. Miele cross-examines Jensen's views on general intelligence (the g factor), racial differences in IQ, cultural bias in IQ tests, and whether differences in IQ are due primarily to heredity or to remediable factors such as poverty and discrimination. With characteristic frankness, Jensen also presents his view of the proper role of scientific facts in establishing public policy, such as Affirmative Action. 'Jensenism' the assertion that heredity plays an undeniably greater role than environmental factors in racial (and other) IQ differences, has entered the dictionary and also made Jensen a bitterly controversial figure. Nevertheless, Intelligence, Race, and Genetics carefully underscores the dedicated lifetime of scrupulously scientific research that supports Jensen's conclusions.

The second edition of the Handbook of Motivation at School presents an integrated compilation of theory and research in the field. With chapters by leading experts, this book covers the major theoretical perspectives in the field as well as their application to instruction, learning, and social adjustment at school. Section I focuses on theoretical perspectives and major constructs, Section II on contextual and social influences on motivation, and Section III on new directions in the field. This new edition will have the same popular organizational structure with theories at the beginning. It will also include new chapters that cover motivation as it relates to identity, culture, test anxiety, mindfulness, neuroscience, parenting, metacognition, and regulatory focus.

In recent decades, globalization has transformed rural societies and economies across the world. Much has been written by social scientists about the actors and structures underpinning these transformations and the effects on particular social groups, organizations and industries. Yet, to date much less attention has been given to the specific global processes that are fundamental to contemporary rural change. Rural Change and Global Processes provides a systematic analysis of the key global processes transforming rural spaces in the early 21st century - financialization; standardization; consumption, and commodification. Through detailed case studies, the book examines why these processes are important, how they work in practice, and the challenges they raise as well as opportunities created. The book will be of particular relevance to researchers, graduate students, and policy-makers interested in the implications of global processes for rural people and livelihoods.

Around 6% of the Earth's land surface is covered by wetlands. Wetlands play a key role in hydrological and biogeochemical cycles, delivering multiple benefits to society: sources of water supply, flood regulation, water purification, agriculture, fisheries, and biodiversity. Hence, wetland systems are of immense socio-economic as well as ecological importance. In this research, the focus was on the Abras de Mantequilla (AdM) wetland in the tropical coastal region of Ecuador, a RAMSAR site and case study area for the EU-FP7 WETwin project. The research in this thesis involves a combination of field data collection, multivariate analysis techniques, as well as numerical modelling studies. The goal was to explore the effects of changes in hydrological forcing on the hydrodynamic and ecohydraulic responses of the wetland. The study aims to contribute to the understanding of how a tropical river-wetland system functions in terms of hydrodynamics, water quality, primary production, and biotic communities. Spatial patterns of biotic communities and environmental variables are obtained as well as spatio-temporal variability of hydrodynamics, water quality, primary productivity and fish habitat-suitability conditions. In data scarce areas and countries with financial constraints, the combination of field measurements with numerical models was extremely useful and relevant, confirming that these techniques complement each other in obtaining a better understanding of the dynamics of freshwater river-wetland systems. Studies like the present research can be used to enhance awareness about the environmental services of wetlands and stimulate cooperation between all stakeholders in order to achieve more sustainable wetland management.

"Optimal Control" reports on new theoretical and practical advances essential for analysing and synthesizing optimal controls of dynamical systems governed by partial and ordinary differential equations. New necessary and sufficient conditions for optimality are given. Recent advances in numerical methods are discussed. These have been achieved through new techniques for solving large-sized nonlinear programs with sparse Hessians, and through a combination of direct and indirect methods for solving the multipoint boundary value problem. The book also focuses on the construction of feedback controls for nonlinear systems and highlights advances in the theory of problems with uncertainty. Decomposition methods of nonlinear systems and new techniques for constructing feedback controls for state- and control constrained linear quadratic systems are presented. The book offers solutions to many complex practical optimal control problems.

This book contains the proceedings ofthe meeting on "Applied Mathematics in the Aerospace Field," held in Erice, Sicily, Italy from September 3 to September 10, 1991. The occasion of the meeting was the 12th Course of the School of Mathematics "Guido Stampacchia," directed by Professor Franco Giannessi of the University of Pisa. The school is affiliated with the International Center for Scientific Culture "Ettore Majorana," which is directed by Professor Antonino Zichichi of the University of Bologna. The objective of the course was to give a perspective on the state-of the-art and research trends concerning the application of mathematics to aerospace science and engineering. The course was structured with invited lectures and seminars concerning fundamental aspects of differential equa tions, mathematical programming, optimal control, numerical methods, per turbation methods, and variational methods occurring in flight mechanics, astrodynamics, guidance, control, aircraft design, fluid mechanics, rarefied gas dynamics, and solid mechanics. The book includes 20 chapters by 23 contributors from the United States, Germany, and Italy and is intended to be an important reference work on the application of mathematics to the aerospace field. It reflects the belief of the course directors that strong interaction between mathematics and engineering is beneficial, indeed essential, to progresses in both areas."

Advanced Design Problems in Aerospace Engineering, Volume 1: Advanced Aerospace Systems presents six authoritative lectures on the use of mathematics in the conceptual design of various types of aircraft and spacecraft. It covers the following topics: design of rocket-powered orbital spacecraft (Miele/Mancuso), design of Moon missions (Miele/Mancuso), design of Mars missions (Miele/Wang), design of an experimental guidance system with a perspective flight path display (Sachs), neighboring vehicle design for a two-stage launch vehicle (Well), and controller design for a flexible aircraft (Hanel/Well). This is a reference book of interest to engineers and scientists working in aerospace engineering and related topics.

Following in the footsteps of the late great Lester Bangs -- the most revered and irreverent of rock 'n' roll critics -- twenty-four celebrated writers have penned stories inspired by great songs. Just as Bangs cast new light on a Rod Stewart classic with his story "Maggie May," about a wholly unexpected connection between an impressionable young man and an aging, alcoholic hooker, the diverse, electrifying stories here use songs as a springboard for a form dubbed the lit riff.

Alongside Bangs's classic work, you'll find stories by J.T. LeRoy, who puts a recovering teenage drug abuser in a dentist's chair with nothing but the Foo Fighters's "Everlong" -- blaring through the P.A. -- to fight the pain; Jonathan Lethem, whose narrator looks back on his lost innocence just as an extramarital affair careens to an end -- this to the tune "Speeding Motorcycle" as recorded by Yo La Tengo; and Jennifer Belle, who envisions a prequel to Paul Simon's "Graceland" -- one that takes place at a children's birthday party replete with a real live kangaroo.

With original contributions from Tom Perrotta, Nelson George, Amanda Davis, Lisa Tucker, Aimee Bender, Darin Strauss, and many more -- riffing on everyone from Tom Waits and Bruce Springsteen to the White Stripes, Cat Power, and Bob Marley -- this is both an astounding collection of short stories and an extraordinary experiment in words and music.

Soundtrack available from Saturation Acres Music & Recording Co.

This book contends that race is a biologically real phenomenon with important consequences, contrary to widespread and politically correct views that race doesn't matter - or doesn't even exist When the head of the Human Genome Project and a former President of the United States both assure us that we are all, regardless of race, genetically 99.9 per cent the same, the clear implication is that racial differences among us are superficial. The concept of race, many would argue, is an inadequate map of the physical reality of human variation. In short, human races are not biologically valid categories, and the very ideas of race and racial difference are morally suspect in that they support racism. In Race, Vincent Sarich and Frank Miele argue strongly against received academic wisdom, contending that human racial differences are both real and significant. Relying on the latest findings in nuclear, mitochondrial, and Y-chromosome DNA research, Sarich and Miele demonstrate that the recent origin of racial differences among modern humans provides powerful evidence of the significance, not the triviality, of those differences. They place the 99.9 per cent the same figure in context by requires forthright recognition of racial differences, public policy should not recognize racial-group membership.

In a series of provocative conversations with "Skeptic" magazine Ssenior editor Frank Miele, renowned University of California-Berkeley psychologist Arthur R. Jensen details the evolution of his thoughts on the nature of intelligence, tracing an intellectual odyssey that leads from the programs of the Great Society to the Bell Curve Wars and beyond. Miele cross-examines Jensen's views on general intelligence (the g factor), racial differences in IQ, cultural bias in IQ tests, and whether differences in IQ are due primarily to heredity or to remediable factors such as poverty and discrimination. With characteristic frankness, Jensen also presents his view of the proper role of scientific facts in establishing public policy, such as Affirmative Action."Jensenism," the assertion that heredity plays an undeniably greater role than environmental factors in racial (and other) IQ differences, has entered the dictionary and also made Jensen a bitterly controversial figure. Nevertheless, "Intelligence, Race, and Genetics" carefully underscores the dedicated lifetime of scrupulously scientific research that supports Jensen's conclusions.