After a one-woman assault on the Umbrella Corporation's fortress, Alice's superhuman abilities are neutralized. Now, fleeing the Undead masses created by the T-virus, Alice reunites with Claire Redfield and her brother, Chris. Together they take refuge with other survivors in an abandoned prison, where a savage zombie mob stands between them and the safety of "Arcadia."

Escaping these bloodthirsty mutants will take an arsenal. But facing off with Albert Wesker and the Umbrella Corporation will take the fight for survival to a new level of danger.

California 1860 and prospector Daniel Dillon (Peter Mullan) has made a fortune in gold and is now running Kingdom Come, a small town built in the heart of the Sierra mountains. He wants to turn the town into a thriving city and to this end he asks Dalglish (Wes Bentley), an engineer plotting the course of the Pacific Railroad Expedition, to survey the surrounding area. But then Dillon's wife (Nastassja Kinski) and twenty-year-old daughter (Sarah Polley), both of whom he had traded for his goldmine years before, arrive in town asking for help. Dillon is overcome with guilt, and leaves his mistress Lucia (Milla Jovovich) in order to seek his wife's forgiveness. Lucia herself then takes up with Dalglish, who tells Dillon that the railroad will not be passing through his town, thereby causing the increasingly-unhinged prospector to reach for his rifle....