In this issue of Surgical Pathology Clinics, guest editor Dr. Ming Zhou brings his considerable expertise to the topic of Genitourinary Pathology. Top experts in the field cover key topics such as prostate cancer: update on grading and reporting; cribriform lesions of the prostate; urothelial carcinoma: divergent differentiation and variants; kidney tumors: new developments in existing WHO kidney tumor entities; and more. Contains 13 relevant, practice-oriented topics including testicular tumors: new developments in germ cell tumors and sex cord stromal tumors; computational pathology in genitourinary pathology; molecular genetics of prostate cancer and role of genomic testing; evolving role of multiparametric MRI in prostate cancer diagnosis and reporting; and more. Provides in-depth clinical reviews on current topics in genitourinary pathology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

With the advent of proteomics came the development of technologies, primarily mass spectrometry, which allowed high-throughput identification of proteins in complex mixtures. While the mass spectrometer resides at the heart of proteomics, its ability to characterize biological samples is only as good as the sample preparation and data analysis tools used in any study. In Proteomics for Biomarker Discovery, expert researchers in the field detail many of the methods which are now commonly used to study proteomics. These include methods and techniques include both label-free approaches and those that utilize stable isotopes incorporated both during cell growth or added via a chemical reaction once the proteome is extracted from the cell. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Proteomics for Biomarker Discovery seeks to aid scientists in the further study the different sample preparation and data analysis tools used in proteomics today.

This book provides in-depth description, explanation, and discussion of goal frustration. It brings together a repertoire of perspectives and strategies that educators and scholars from diverse educational contexts have conceptualized and/or implemented in order to monitor, control, or overcome the occurrence of frustration. This book describes the new technologies can be applied in the conceptualization and operationalization of goal frustration. It also discusses the strategies and pedagogies we can use to cope with this emotion. This book offers evidence-based reports of goal frustration as well as data-driven approaches by presenting both theoretical account and empirical evidence that are grounded in educational and psychological research. This work will appeal to a wider readership from practitioners, parents, to educational researchers.

This book aims to incorporate an emerging successful business model, i.e., sharing economy, into energy markets, thus digging out the potential merits and applications in multi-energy sectors. With the core idea "access over ownership", sharing economy enables the collaborative consumption of idle resources through advanced information and communications technology. One critical challenge is to identify different market participants' occupation while accordingly designing pricing mechanisms. This book begins with an overview about the recent development of sharing economy in energy fields, and summarizes two energy market-related issues that sharing economy can hopefully address. One is how to quantify a marginal generator's contribution and thereby elicit truthful bidding under information asymmetry condition. The other is how to distinguish renewable and distributed energy resources' contribution and thus incentivize efficient aggregation considering increasing scale and uncertainty. Then sharing economy mechanisms are proposed and designed from a game theory perspective. On this basis, the following chapters thoroughly investigate the specific problems in spot markets, multi-area markets, renewable energy aggregation and energy systems integration. Additionally, the benefits brought by sharing economy are evaluated in terms of regional market bidding and transmission expansion deferral. Finally, the information and communications technologies related to sharing economy are modeled and analyzed. Hopefully, this book can greatly benefit the readers who are interested in energy economics and engineering.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

Uropathology, a volume in the High Yield Pathology Series, makes it easy to recognize the classic manifestations of urologic diseases and quickly confirm your diagnoses. A templated format, excellent color photographs, authoritative content, and online access make Uropathology an ideal reference for busy pathologists. Provides in-depth, bulleted outlines for each entity covering definition, anatomy, and pathology: histology, immunohistochemistry, and differential diagnosis. Features 1,600 high-quality illustrations that include gross, radiographic imaging, microscopic, immunohistochemical, and special stains, providing a comprehensive visual summary of the typical features of each entity. Includes expanded information on tumor staging expertly provided by Dr. Ming Zhou, primary author of the College of American Pathologists cancer protocols. Reflects recent guidelines and protocols including: Restructured tumor classification and new entities New and modified grading systems for GU cancers New and modified staging criteria for all GU cancers New recommendations for reporting New IHC and molecular markers for diagnosis and prognosis for GU cancers Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices Your first line resource for genitourinary pathology

Challenging Nobel economics laureate Theodore W. Schultz, Dr Zhou, in this comparative and path-breaking work, presents a new model for private land ownership or possession to overcome inefficient land-holding, increase farm competitiveness, realize food self-sufficiency and eliminate poverty. He aims to consolidate and enlarge fragmented small farms persisting in Asia, the Pacific, Africa, Latin America, and Central, Eastern and Southern Europe; and to help preserve small farmers, while strengthening large farmers, in the USA, OECD and EU. He introduces the means to facilitate the transition of collectively operated large farms in Central and Eastern Europe and Central Asia; promote EU enlargement; to prevent food overproduction; and to improve the environment. He also analyzes China's experience with public land ownership and makes important contributions to both new institutional economics and evolutionary political economy.

This book constitutes the refereed proceedings of the Second China Conference on Knowledge Graph and Semantic Computing, CCKS 2017, held in Chengdu, China, in August 2017. The 11 revised full papers and 6 revised short papers presented were carefully reviewed and selected from 85 submissions. The papers cover wide research fields including the knowledge graph, the Semantic Web, linked data, NLP, knowledge representation, graph databases.

With the advent of proteomics came the development of technologies, primarily mass spectrometry, which allowed high-throughput identification of proteins in complex mixtures. While the mass spectrometer resides at the heart of proteomics, its ability to characterize biological samples is only as good as the sample preparation and data analysis tools used in any study. In Proteomics for Biomarker Discovery, expert researchers in the field detail many of the methods which are now commonly used to study proteomics. These include methods and techniques include both label-free approaches and those that utilize stable isotopes incorporated both during cell growth or added via a chemical reaction once the proteome is extracted from the cell. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Proteomics for Biomarker Discovery seeks to aid scientists in the further study the different sample preparation and data analysis tools used in proteomics today.

This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.

This book constitutes the refereed proceedings of the First CCF Conference, NLPCC 2012, held in Beijing, China, during October/November, 2012. The 43 revised full papers presented were carefully reviewed and selected from 151 submissions. The papers are organized in topical sections on applications on language computing; fundamentals on language computing; machine translation and multi-lingual information access; NLP for search, ads and social networks; question answering and Web mining.

TheAsiaInformationRetrievalSymposium(AIRS)wasestablishedbytheAsian information retrieval community after the successful series of Information - trieval with Asian Languages (IRAL) workshops held in six di?erent locations in Asia, starting from 1996. While the IRAL workshops had their focus on inf- mation retrieval problems involving Asian languages, AIRS covers a wider scope of applications, systems, technologies and theory aspects of information retrieval in text, audio, image, video and multimedia data. This extension of the scope re?ects and fosters increasing research activities in information retrieval in this region and the growing need for collaborations across subdisciplines. We are very pleased to report that we saw a sharp increase in the number of submissions and their quality, compared to the IRAL workshops. We received 106papersfromninecountriesinAsiaandNorthAmerica, fromwhich28papers (26%) were presented in oral sessions and 38 papers in poster sessions (36%). It was a great challenge for the Program Committee to select the best among the excellent papers. The low acceptance rates witness the success of this year's conference. After a long discussion between the AIRS 2004 Steering Committee and Springer, the publisher agreed to publish our proceedings in the Lecture Notes in Computer Science (LNCS) series, which is SCI-indexed. We feel that this strongly attests to the excellent quality of the papers.

The ethnological and anthropological significance of animals is common to all cultures and periods. Given this fact, the book essays a comparative study of the animal figures in the works of a representative of Chinese literature - Pu Songling (1640-1715) - and those found in the works of a German-speaking writer, Franz Kafka (1883-1924). The first chapter establishes the basic characteristics of the animal figures of the two authors and then proceeds to place these in the broader context of categories such as the grotesque, metamorphosis, animal parable and animal comparison, with copious reference to the different cultural and literary traditions. Jianming Zhou undertakes detailed textual analyses and comparisons with a view to illuminating Kafkas approach to Pus work and the development of his style in the portrayal of animals and humans. In so doing he suceeds in pointing up the influence of Pu Songling on Kafka and thus opening up new perspectives for intercultural comparative research on Kafkas work.

This book aims to incorporate an emerging successful business model, i.e., sharing economy, into energy markets, thus digging out the potential merits and applications in multi-energy sectors. With the core idea “access over ownership”, sharing economy enables the collaborative consumption of idle resources through advanced information and communications technology. One critical challenge is to identify different market participants’ occupation while accordingly designing pricing mechanisms. This book begins with an overview about the recent development of sharing economy in energy fields, and summarizes two energy market-related issues that sharing economy can hopefully address. One is how to quantify a marginal generator’s contribution and thereby elicit truthful bidding under information asymmetry condition. The other is how to distinguish renewable and distributed energy resources’ contribution and thus incentivize efficient aggregation considering increasing scale and uncertainty. Then sharing economy mechanisms are proposed and designed from a game theory perspective. On this basis, the following chapters thoroughly investigate the specific problems in spot markets, multi-area markets, renewable energy aggregation and energy systems integration. Additionally, the benefits brought by sharing economy are evaluated in terms of regional market bidding and transmission expansion deferral. Finally, the information and communications technologies related to sharing economy are modeled and analyzed. Hopefully, this book can greatly benefit the readers who are interested in energy economics and engineering.