This book provides a timely review of the role of histone
modifications in epigenetic control of gene expression. Topics
covered include: basic mechanisms of molecular recognition of
histone post-translational modification (PTMs); combinatorial
readout of histone PTMs by tandem epigenome reader domains;
genome-wide profiling of histone PTM interactions; small molecule
modulation of histone PTM interactions and their potential as a new
approach to therapeutic intervention in human diseases. All
chapters were written by leading scientists who made the original
key discoveries of the structure and mechanism of evolutionarily
conserved reader domains, which serve to direct gene transcription
in chromatin through interactions with DNA-packing histones in a
PTM-sensitive manner.
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