Oryzias latipes, known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

"Oryzias latipes," known as medaka, is a model organism from East Asia. Breeding of this small, egg-laying freshwater teleost fish has long been popular among hobbyists in Japan. Now, as biological science has entered the genome era, the medaka provides significant advantages that make it one of the most valuable vertebrate models: a large collection of spontaneous mutants collected over a century, the presence of highly polymorphic inbred lines established over decades, and a recently completed genome sequence. This book is the first comprehensive monograph to cover a variety of medaka research. It opens with a historical view of medaka, followed by a series of research topics in the four major areas where the medaka is increasingly important: genomics, genetics, and resources; organogenesis and disease models; germ cells, sex determination, and reproduction; and evolution. Readers will find state-of-the-art information on medaka genetics and genomics such as the first isolation of active transposons in vertebrates, the influence of chromatin structure on sequence variation, fine QTL analysis, and versatile mutants as human disease models.

In eighteenth-century Japan, Tsunetomo Yamamoto created the Hagakure, a document that served as the basis for samurai warrior behavior. Its guiding principles greatly influenced the Japanese ruling class and shaped the underlying character of the Japanese psyche, from businessmen to soldiers. Bushido is the first English translation of the Hagakure. This work provides a powerful message aimed at the mind and spirit of the samurai warrior. It offers beliefs that are difficult for the Western mind to embrace, yet fascinating in their pursuit of absolute service. With Bushido, one can better put into perspective Japan's historical path and gain greater insight into the Japan of today.

This independent account of modern ideas in differential geometry shows how they can be used to understand and extend classical results in integral geometry. The authors explore the influence of total curvature on the metric structure of complete, non-compact Riemannian 2-manifolds, although their work can be extended to more general spaces. Each chapter features open problems, making the volume a suitable learning aid for graduate students and non-specialists who seek an introduction to this modern area of differential geometry.