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In this volume of Methods in Molecular Biology (TM), expert
investigators offer comprehensive, complementary, and cutting-edge
technologies for studies of gene regulation. The chapters of Gene
Regulation: Methods and Protocols are organized to provide an
integrated and a coherent view of control systems and their
associated components. The protocols are broad in their scope. They
include molecular, biochemical, spectroscopic techniques as well as
high throughput strategies. Written in the highly successful
Methods in Molecular Biology (TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls. Comprehensive and broad in their scope, the
protocols are useful to researchers in many disciplines including
molecular biology, genomics, biochemistry, biomedicine, nutrition,
and agricultural sciences.
In this volume of Methods in Molecular Biology (TM), expert
investigators offer comprehensive, complementary, and cutting-edge
technologies for studies of gene regulation. The chapters of Gene
Regulation: Methods and Protocols are organized to provide an
integrated and a coherent view of control systems and their
associated components. The protocols are broad in their scope. They
include molecular, biochemical, spectroscopic techniques as well as
high throughput strategies. Written in the highly successful
Methods in Molecular Biology (TM) series format, chapters include
introductions to their respective topics, lists of the necessary
materials and reagents, step-by-step, readily reproducible
laboratory protocols, and key tips on troubleshooting and avoiding
known pitfalls. Comprehensive and broad in their scope, the
protocols are useful to researchers in many disciplines including
molecular biology, genomics, biochemistry, biomedicine, nutrition,
and agricultural sciences.
Completion of the sequence of the human genome represents an unpar-
leled achievement in the history of biology. The project has
produced nearly complete, highly accurate, and comprehensive
sequences of genomes of s- eral organisms including human, mouse,
drosophila, and yeast. Furthermore, the development of
high-throughput technologies has led to an explosion of projects to
sequence the genomes of additional organisms including rat, chimp,
dog, bee, chicken, and the list is expanding. The nearly completed
draft of genomic sequences from numerous species has opened a new
era of research in biology and in biomedical sciences. In keeping
with the interdisciplinary nature of the new scientific era, the
chapters in Gene Mapping, Discovery, and Expression: Methods and
Protocols recapitulate the necessity of integration of experimental
and computational tools for solving - portant research problems.
The general underlying theme of this volume is DNA sequence-based
technologies. At one level, the book highlights the importance of
databases, genome-browsers, and web-based tools for data access and
ana- sis. More specifically, sequencing projects routinely deposit
their data in p- licly available databases including GenBank, at
the National Center of Biotechnology (NCBI) in the United States;
EMBL, maintained by the European Bioinformatics Institute; and
DDBJ, the DNA Data Bank of Japan. Currently, several browsers offer
facile access to numerous genomic DNA sequences for gene mapping
and data retrieval.
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