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Thin layer chromatography (TLC) is increasingly used in the fields
of plant chemistry, biochemistry, and molecular biology. Advantages
such as speed, versatility, and low cost make it one of the leading
techniques used for locating and analyzing bioactive components in
plants. Thin Layer Chromatography in Phytochemistry is the first
source devoted to supplying state-of-the-art information on TLC as
it applies to the separation, identification, quantification, and
isolation of medicinal plant components. Renowned scientists
working with laboratories around the world demonstrate the
applicability of TLC to a remarkable diversity of fields including
plant genetics, drug discovery, nutraceuticals, and toxicology.
Elucidates the role of plant materials in the pharmaceutical
industry... Part I provides a practical review of techniques,
relevant materials, and the particular demands for using TLC in
phytochemical applications. The text explains how to determine the
biological activity of metabolites and assess the effectiveness of
herbal medicines and nutritional supplements. Part II concentrates
on TLC methods used to analyze specific plant-based metabolite
classes such as carbohydrates, proteins, alkaloids, flavonoids,
terpenes, etc. Organized by compound type, each chapter discusses
key topics such as sample preparation, plate development, zone
detection, densitometry, and biodetection. Demonstrates practical
methods that can be applied to a wide range of disciplines... From
identification to commercial scale production and quality control,
Thin Layer Chromatography in Phytochemistry is an essential
bench-top companion and reference on using TLC for the study of
plant-based bioactive compounds.
Used routinely in drug control laboratories, forensic laboratories,
and as a research tool, thin layer chromatography (TLC) plays an
important role in pharmaceutical drug analyses. It requires less
complicated or expensive equipment than other techniques, and has
the ability to be performed under field conditions. Filling the
need for an up-to-date, complete reference, Thin Layer
Chromatography in Drug Analysis covers the most important methods
in pharmaceutical applications of TLC, namely, analysis of bulk
drug material and pharmaceutical formulations, degradation studies,
analysis of biological samples, optimization of the separation of
drug classes, and lipophilicity estimation. The book is divided
into two parts. Part I is devoted to general topics related to TLC
in the context of drug analysis, including the chemical basis of
TLC, sample pleparation, the optimization of layers and mobile
phases, detection and quantification, analysis of ionic compounds,
and separation and analysis of chiral substances. The text
addresses the newest advances in TLC instrumentation,
two-dimensional TLC, quantification by slit scanning densitometry
and image analysis, statistical processing of data, and various
detection and identification methods. It also describes the use of
TLC for solving a key issue in the drug market-the presence of
substandard and counterfeit pharmaceutical products. Part II
provides an in-depth overview of a wide range of TLC applications
for separation and analysis of particular drug groups. Each chapter
contains an introduction about the structures and medicinal actions
of the described substances and a literature review of their TLC
analysis. A useful resource for chromatographers, pharmacists,
analytical chemists, students, and R&D, clinical, and forensic
laboratories, this book can be utilized as a manual, reference, and
teaching source.
Thin layer chromatography (TLC) is increasingly used in the fields
of plant chemistry, biochemistry, and molecular biology. Advantages
such as speed, versatility, and low cost make it one of the leading
techniques used for locating and analyzing bioactive components in
plants. Thin Layer Chromatography in Phytochemistry is the first
source devoted to supplying state-of-the-art information on TLC as
it applies to the separation, identification, quantification, and
isolation of medicinal plant components. Renowned scientists
working with laboratories around the world demonstrate the
applicability of TLC to a remarkable diversity of fields including
plant genetics, drug discovery, nutraceuticals, and toxicology.
Elucidates the role of plant materials in the pharmaceutical
industry... Part I provides a practical review of techniques,
relevant materials, and the particular demands for using TLC in
phytochemical applications. The text explains how to determine the
biological activity of metabolites and assess the effectiveness of
herbal medicines and nutritional supplements. Part II concentrates
on TLC methods used to analyze specific plant-based metabolite
classes such as carbohydrates, proteins, alkaloids, flavonoids,
terpenes, etc. Organized by compound type, each chapter discusses
key topics such as sample preparation, plate development, zone
detection, densitometry, and biodetection. Demonstrates practical
methods that can be applied to a wide range of disciplines... From
identification to commercial scale production and quality control,
Thin Layer Chromatography in Phytochemistry is an essential
bench-top companion and reference on using TLC for the study of
plant-based bioactive compounds.
The powerful, efficient technique of high performance liquid
chromatography (HPLC) is essential to the standardization of
plant-based drugs, identification of plant material, and creation
of new herbal medicines. Filling the void in this critical area,
High Performance Liquid Chromatography in Phytochemical Analysis is
the first book to give a complete description of the techniques,
materials, and instrumentation of column HPLC and its application
to essentially all primary and secondary plant metabolites. Hailing
from around the world and with vast expertise in HPLC phytochemical
analysis, the contributors present a global, authoritative view of
the field. The book looks at the role of HPLC in the analysis of
herbal drugs, quality control of plant products in dietary
supplements, and chemosystematics. It also covers the
phytochemistry, pharmacology, and biological role of plant
metabolites as well as various modes and techniques of HPLC
analysis. The book then focuses on HPLC separation, identification,
and quantification of particular classes of compounds in a variety
of sample types, including plants, plant extracts, and
plant-derived products. Along with its companion volume Thin Layer
Chromatography in Phytochemistry, this comprehensive book presents
the most important analytical approaches used in phytochemical
analysis. It will help in solving problems connected with practical
separations and the analyses of plant extract fractions of active
metabolites.
Used routinely in drug control laboratories, forensic laboratories,
and as a research tool, thin layer chromatography (TLC) plays an
important role in pharmaceutical drug analyses. It requires less
complicated or expensive equipment than other techniques, and has
the ability to be performed under field conditions. Filling the
need for an up-to-date, complete reference, Thin Layer
Chromatography in Drug Analysis covers the most important methods
in pharmaceutical applications of TLC, namely, analysis of bulk
drug material and pharmaceutical formulations, degradation studies,
analysis of biological samples, optimization of the separation of
drug classes, and lipophilicity estimation. The book is divided
into two parts. Part I is devoted to general topics related to TLC
in the context of drug analysis, including the chemical basis of
TLC, sample pleparation, the optimization of layers and mobile
phases, detection and quantification, analysis of ionic compounds,
and separation and analysis of chiral substances. The text
addresses the newest advances in TLC instrumentation,
two-dimensional TLC, quantification by slit scanning densitometry
and image analysis, statistical processing of data, and various
detection and identification methods. It also describes the use of
TLC for solving a key issue in the drug market-the presence of
substandard and counterfeit pharmaceutical products. Part II
provides an in-depth overview of a wide range of TLC applications
for separation and analysis of particular drug groups. Each chapter
contains an introduction about the structures and medicinal actions
of the described substances and a literature review of their TLC
analysis. A useful resource for chromatographers, pharmacists,
analytical chemists, students, and R&D, clinical, and forensic
laboratories, this book can be utilized as a manual, reference, and
teaching source.
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