Used routinely in drug control laboratories, forensic laboratories,
and as a research tool, thin layer chromatography (TLC) plays an
important role in pharmaceutical drug analyses. It requires less
complicated or expensive equipment than other techniques, and has
the ability to be performed under field conditions. Filling the
need for an up-to-date, complete reference, Thin Layer
Chromatography in Drug Analysis covers the most important methods
in pharmaceutical applications of TLC, namely, analysis of bulk
drug material and pharmaceutical formulations, degradation studies,
analysis of biological samples, optimization of the separation of
drug classes, and lipophilicity estimation. The book is divided
into two parts. Part I is devoted to general topics related to TLC
in the context of drug analysis, including the chemical basis of
TLC, sample pleparation, the optimization of layers and mobile
phases, detection and quantification, analysis of ionic compounds,
and separation and analysis of chiral substances. The text
addresses the newest advances in TLC instrumentation,
two-dimensional TLC, quantification by slit scanning densitometry
and image analysis, statistical processing of data, and various
detection and identification methods. It also describes the use of
TLC for solving a key issue in the drug market-the presence of
substandard and counterfeit pharmaceutical products. Part II
provides an in-depth overview of a wide range of TLC applications
for separation and analysis of particular drug groups. Each chapter
contains an introduction about the structures and medicinal actions
of the described substances and a literature review of their TLC
analysis. A useful resource for chromatographers, pharmacists,
analytical chemists, students, and R&D, clinical, and forensic
laboratories, this book can be utilized as a manual, reference, and
teaching source.
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