One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.

From the Foreword..... Modern digital signal processing applications provide a large challenge to the system designer. Algorithms are becoming increasingly complex, and yet they must be realized with tight performance constraints. Nevertheless, these DSP algorithms are often built from many constituent canonical subtasks (e.g., IIR and FIR filters, FFTs) that can be reused in other subtasks. Design is then a problem of composing these core entities into a cohesive whole to provide both the intended functionality and the required performance. In order to organize the design process, there have been two major approaches. The top-down approach starts with an abstract, concise, functional description which can be quickly generated. On the other hand, the bottom-up approach starts from a detailed low-level design where performance can be directly assessed, but where the requisite design and interface detail take a long time to generate. In this book, the authors show a way to effectively resolve this tension by retaining the high-level conciseness of VHDL while parameterizing it to get good fit to specific applications through reuse of core library components. Since they build on a pre-designed set of core elements, accurate area, speed and power estimates can be percolated to high- level design routines which explore the design space. Results are impressive, and the cost model provided will prove to be very useful. Overall, the authors have provided an up-to-date approach, doing a good job at getting performance out of high-level design. The methodology provided makes good use of extant design tools, and is realistic in terms of the industrial design process. The approach is interesting in its own right, but is also of direct utility, and it will give the existing DSP CAD tools a highly competitive alternative. The techniques described have been developed within ARPAs RASSP (Rapid Prototyping of Application Specific Signal Processors) project, and should be of great interest there, as well as to many industrial designers. Professor Jonathan Allen, Massachusetts Institute of Technology

From the Foreword..... Modern digital signal processing applications provide a large challenge to the system designer. Algorithms are becoming increasingly complex, and yet they must be realized with tight performance constraints. Nevertheless, these DSP algorithms are often built from many constituent canonical subtasks (e.g., IIR and FIR filters, FFTs) that can be reused in other subtasks. Design is then a problem of composing these core entities into a cohesive whole to provide both the intended functionality and the required performance. In order to organize the design process, there have been two major approaches. The top-down approach starts with an abstract, concise, functional description which can be quickly generated. On the other hand, the bottom-up approach starts from a detailed low-level design where performance can be directly assessed, but where the requisite design and interface detail take a long time to generate. In this book, the authors show a way to effectively resolve this tension by retaining the high-level conciseness of VHDL while parameterizing it to get good fit to specific applications through reuse of core library components. Since they build on a pre-designed set of core elements, accurate area, speed and power estimates can be percolated to high- level design routines which explore the design space. Results are impressive, and the cost model provided will prove to be very useful. Overall, the authors have provided an up-to-date approach, doing a good job at getting performance out of high-level design. The methodology provided makes good use of extant design tools, and is realistic in terms of the industrial design process. The approach is interesting in its own right, but is also of direct utility, and it will give the existing DSP CAD tools a highly competitive alternative. The techniques described have been developed within ARPAs RASSP (Rapid Prototyping of Application Specific Signal Processors) project, and should be of great interest there, as well as to many industrial designers. Professor Jonathan Allen, Massachusetts Institute of Technology

One ofthe major drivers in biological research is the establishment ofstructures and functions of the 50,000 or so proteins in our bodies. Each has a characteristic- dimensional structure, highly "ordered" yet "disordered"! This structure is essential for a protein's function and, significantly, it must be sustained in the competitive and complex environment of the living cell. It is now being recognised that when a cell loses control, proteins can se- assemble into more complex supermolecular structures such as the amyloid fibres and plaques associated with the pathogenesis of prion (CJD) or age-related (Alzheimer's) diseases. This is a pointer to the wider significance of the self-assembling properties of polypeptides. It has been long known that, in silk, polypeptides are assembled into- sheet structures which impart on the material its highly exploitable properties of flexibility combined with high tensile strength. But only now emerging is the recognition that peptides can Self-assemble into a wide variety of non-protein-like structures, including fibrils, fibres, tubules, sheets and monolayers. These are exciting observations and, more so, the potential for materials and medical exploitations is so wide ranging that over 80 scientists from Europe, USA, Japan and Israel. met 1-6 July 1999 in Crete, to discuss the wide-ranging implications of these novel developments. There was a spirit of excitement about the workshop indicative of an important new endeavor. The emerging perception is that of a new class of materials set to become commercially viable early in the 21st century.