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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.
Originally published in 1975, this book was something of a pioneering study. It examines the three main traditions of African educational development – indigenous, Islamic and ‘Western’ – and the resulting harmonies and conflicts that arise from these traditions. Its contributors are all specialists writing about their own particular area of interest covering many countries of tropical Africa. They include a number of well-known African scholars as well as some comparatively new names in the field of African Studies at the time. A feature of the book is the attention that it gives to the education of women – an aspect of ‘nation-building’ that had often been rather neglected. This study is an inter-disciplinary work, calling into contribution History, Sociology, Anthropology, Law, Linguistics, and Medicine, as well as Education. It seeks to show how complex the educational situation is in Africa – and how this complexity needs to be appreciated as a background to educational planning. Nobody who has read this volume will be inclined to dismiss educational reform in Africa as ‘a relatively simple matter’ – a point of view too frequently implied by those who have not studied the subject in depth. ‘Off with the old – on with the new’ cannot be so easily implemented as critics within and without the continent sometimes seem to think. More constructively, however, this volume provides many useful insights into ways in which social tension may be reduced and harmony promoted in, and through, education. Although it is likely to be of most immediate value to those who are concerned with African education and its administration (especially in teacher-education), the book constitutes a significant contribution to understanding problems of ‘development’.
A rich history, larger-than-life personalities, and independent spirit make Texas a treasure trove of ghostly lore. This collection, drawn from the deserts of the west to the beaches of the Gulf Shore, includes eerie tales of the spirits that haunt the Alamo, Old Rip the horned toad, UFO sightings in north Texas, the never-ending ride of El Muerto, the ghost on board the USS Lexington, and the watchful specter of Miss Bettie at Galveston's Ashton Villa.
Essays on women and devotional literature in the Middle Ages in commemoration and celebration of the respected feminist scholar Catherine Innes-Parker. Silence was a much-lauded concept in the Middle Ages, particularly in the context of religious literature directed at women. Based on the Pauline prescription that women should neither preach nor teach, and should at all times keep speech to a minimum, the concept of silence lay at the forefront of many devotional texts, particularly those associated with various forms of women's religious enclosure. Following the example of the Virgin Mary, religious women were exhorted to speak seldom, and then only seriously and devoutly. However, as this volume shows, such gendered exhortations to silence were often more rhetorical than literal. The contributions range widely: they consider the English 'Wooing Group' texts and female-authored visionary writings from the Saxon nunnery of Helfta in the thirteenth century; works by Richard Rolle and the Dutch mystic Jan van Ruusbroec in the fourteenth century; Anglo-French treatises, and books housed in the library of the English noblewoman Cecily Neville in the fifteenth century; and the resonant poetics of women from non-Christian cultures. But all demonstrate the ways in which silence, rather than being a mere absence of speech, frequently comprised a form of gendered articulation and proto-feminist point of resistance. They thus provide an apt commemoration and celebration of the deeply innovative work of Catherine Innes-Parker (1956-2019), the respected feminist scholar and a pioneer of this important field of study.
Originally published in 1975, this book was something of a pioneering study. It examines the three main traditions of African educational development - indigenous, Islamic and 'Western' - and the resulting harmonies and conflicts that arise from these traditions. Its contributors are all specialists writing about their own particular area of interest covering many countries of tropical Africa. They include a number of well-known African scholars as well as some comparatively new names in the field of African Studies at the time. A feature of the book is the attention that it gives to the education of women - an aspect of 'nation-building' that had often been rather neglected. This study is an inter-disciplinary work, calling into contribution History, Sociology, Anthropology, Law, Linguistics, and Medicine, as well as Education. It seeks to show how complex the educational situation is in Africa - and how this complexity needs to be appreciated as a background to educational planning. Nobody who has read this volume will be inclined to dismiss educational reform in Africa as 'a relatively simple matter' - a point of view too frequently implied by those who have not studied the subject in depth. 'Off with the old - on with the new' cannot be so easily implemented as critics within and without the continent sometimes seem to think. More constructively, however, this volume provides many useful insights into ways in which social tension may be reduced and harmony promoted in, and through, education. Although it is likely to be of most immediate value to those who are concerned with African education and its administration (especially in teacher-education), the book constitutes a significant contribution to understanding problems of 'development'.
Originally published in 1967, this book represents the late Professor Brown’s twin skills as historian and as educationalist at their best. It is one of a series of books which he edited, and which was offered to Africa teachers in training. The series was designed to help those who were called upon to teach the many subjects of the primary school curriculum or two or more subjects with the junior forms of secondary schools. It is dedicated to the proposition that giving a good basic education to a country’s children is vital to its development programme. Godfrey Brown’s book starts with a discussion of the place and purpose of history in education – why do we teach it to children? He then describes methods of teaching language skills in history, observation and (at some length) social development through history. He ends with The History of the Future and two practical appendices listing where the African teacher of history could obtain useful teaching material.
Originally published in 1967, this book represents the late Professor Brown's twin skills as historian and as educationalist at their best. It is one of a series of books which he edited, and which was offered to Africa teachers in training. The series was designed to help those who were called upon to teach the many subjects of the primary school curriculum or two or more subjects with the junior forms of secondary schools. It is dedicated to the proposition that giving a good basic education to a country's children is vital to its development programme. Godfrey Brown's book starts with a discussion of the place and purpose of history in education - why do we teach it to children? He then describes methods of teaching language skills in history, observation and (at some length) social development through history. He ends with The History of the Future and two practical appendices listing where the African teacher of history could obtain useful teaching material.
Essays exploring the great religious and devotional works of the Middle Ages in their manuscript and other contexts. Michael G. Sargent's scholarship on late medieval English devotional literature has been hugely influential on the fields of Middle English literature, religious studies, and manuscript studies. His prolific work on a great range of English and French texts, including visionary writing, devotional guidance, and drama, devoting scrupulous attention to the physical forms in which these texts circulated, has established the scope and impact of religious writing across the social spectrum in England, enabling a nuanced understanding of the complex literary interactions between the cloister and the world. The essays in this volume demonstrate and pay tribute to Sargent's influence, extending and complementing his work on devotional texts and the books in which they traveled. The themes of translation, manuscript transmission and the varieties of devotional practice are to the fore. Inspired by Sargent's work on Love's Middle English translation of pseudo-Bonaventuran devotional texts, some chapters explore other Middle English translations within this tradition, considering the implications of translation strategies for shaping readers' practices, while others examine Carthusian and Birgittine texts as they appear in new contexts, probing the continuing influence of these orders on devotional life and theological controversy. Whether looking at devotional guidance, visionary texts, or hagiography, each contribution works closely with texts in their material contexts, always considering a question central to Sargent's scholarship: how texts gain distinct cultural meanings within particular circumstances of copying, transmission and ownership.
Barking Abbey (founded c. 666) is hugely significant for those studying the literary production by and patronage of medieval women. It had one of the largest libraries of any English nunnery, and a history of women's education from the Anglo-Saxon period to the Dissolution; it was also the home of women writers of Latin and Anglo-Norman works, as well as of many Middle English manuscript books.BR> The essays in this volume map its literary history, offering a wide-ranging examination of its liturgical, historio-hagiographical, devotional, doctrinal, and administrative texts, with a particular focus on the important hagiographies produced there during the twelfth century. It thus makes a major contribution to the literary and cultural history of medieval England and a rich resource for the teaching of women's texts. Professor Jennifer N. Brown teaches at Marymount Manhattan College; Professor Donna Alfano Bussell teaches at University of Illinois-Springfield. Contributors: Diane Auslander, Alexandra Barratt, Emma Berat, Jennifer N. Brown, Donna A. Bussell, Thelma Fenster, Stephanie Hollis, Thomas O'Donnell, Delbert Russell, Jill Stevenson, Kay Slocum, Lisa Weston, Jocelyn Wogan-Browne, Anne B. Yardley
This accessible introduction shows the reader how to understand, implement, adapt, and apply Learning Classifier Systems (LCSs) to interesting and difficult problems. The text builds an understanding from basic ideas and concepts. The authors first explore learning through environment interaction, and then walk through the components of LCS that form this rule-based evolutionary algorithm. The applicability and adaptability of these methods is highlighted by providing descriptions of common methodological alternatives for different components that are suited to different types of problems from data mining to autonomous robotics. The authors have also paired exercises and a simple educational LCS (eLCS) algorithm (implemented in Python) with this book. It is suitable for courses or self-study by advanced undergraduate and postgraduate students in subjects such as Computer Science, Engineering, Bioinformatics, and Cybernetics, and by researchers, data analysts, and machine learning practitioners.
Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.
This volume constitutes the proceedings of the 10th International Conference on Simulated Evolution and Learning, SEAL 2012, held in Dunedin, New Zealand, in December 2014. The 42 full papers and 29 short papers presented were carefully reviewed and selected from 109 submissions. The papers are organized in topical sections on evolutionary optimization; evolutionary multi-objective optimization; evolutionary machine learning; theoretical developments; evolutionary feature reduction; evolutionary scheduling and combinatorial optimization; real world applications and evolutionary image analysis.
Continual improvements in data collection and processing have had a huge impact on brain research, producing data sets that are often large and complicated. By emphasizing a few fundamental principles, and a handful of ubiquitous techniques, Analysis of Neural Data provides a unified treatment of analytical methods that have become essential for contemporary researchers. Throughout the book ideas are illustrated with more than 100 examples drawn from the literature, ranging from electrophysiology, to neuroimaging, to behavior. By demonstrating the commonality among various statistical approaches the authors provide the crucial tools for gaining knowledge from diverse types of data. Aimed at experimentalists with only high-school level mathematics, as well as computationally-oriented neuroscientists who have limited familiarity with statistics, Analysis of Neural Data serves as both a self-contained introduction and a reference work.
The IUTAM Symposium on Boundary-Layer Separation, suggested by the UK National Committee of Theoretical and Applied Mechanics and supported by the International Union of Theoretical and Applied Mechanics, was held at University College London on August 26-28, 1986. The proposed theme and scope of the Symposium were designed to help to bring about the necessary interaction between experimentalists, computationalists and theoreticians for the furthering of understanding in this challenging subject. The talks and discussions were aimed at representing the very wide range and application of separating-flow phenomena, which often substantially affect the whole of fluid dynamics at medium to large Reynolds numbers, covering in particular both laminar and turbulent flow, steady or unsteady, two- or three-dimensional, small or large-scale, incompressible or compressible, external or internal, from the experimental, computational and theoretical standpoints. It was intended that about 80 scientists would participate in the Symposium, with about 25 talks being delivered, to which poster sessions with 8 contributions were added subsequently. All the speakers and poster presenters were selected by the scientific committee, although two late replacements of speakers were required. Fruitful discussions, well led by the session chairmen, took place formally after each talk and after the poster sessions and informally on other occasions including the social events. The present proceedings of the Symposium appear to reflect much of the current state of experimental, computational and theoretical work and progress in boundary-layer separation. We hope that they provide also ideas, questions and stimulation, in addition to major recent developments."
Proceedings of the Physiology Working Group Technical Session Society of American Foresters National Convention, Portland, Oregon, USA, October 16-20, 1983
Since the greenhouse effect emerged as a predictable threat, necessitating the evalu ation of its future impact on the environment in the various parts of the globe, interest in the climate changes during the Holocene has gained momentum. The background can be summarized by the sentence: The past is a key to the future. As a matter of fact, this sentence is in the opposite direction, on the dimension of time, to the principle adopted by the founders of the science of geology. They proposed that geological processes in the present should be used as a key for understanding the past. Another reason for the interest in the history of the climate of the Holocene can be described as the renaissance of a modified deterministic approach to the inter relation between physical and human geography. This relates in the first place to the fact that various investigations, especially as carried out by Hubert Lamb, showed that the sequence of climate changes previously suggested by Blytt and Sernander for Europe and adopted by most Holocene climatologists was far too general, and that there were more climate changes during recent history than previously taken account of. In the second place it was found out that these changes had had an impact on the history of human communities. Thus, one can conclude that once the taboo on geographical determinism (i. e."
This open access book explores the past and present of Quanzhou (Zayton) and the rich diversity and tolerance that kindled Quanzhou's innovativeness and helped it prosper both commercially and culturally-values that are today being embraced by China's global trade partners. Quanzhou (Zayton), Marco Polo's port of departure and Columbus' goal in China, was not only the start of the Maritime Silk Road and the Middle Age's greatest port but also centuries ahead of its time in its tolerance and diversity. The fabled "City of Light" had 7 mosques for its 40,000 Muslims, some of whom served in government, as well as 3 Franciscan cathedrals funded in part by the emperor, Jewish synagogues, and centers for Nestorian Christians, Hindus, Taoists, Manicheans, Jains, etc. As Franciscan Bishop Andrew of Perugia wrote in 1322, "Tis a fact that in this vast empire, there are people of every nation under heaven, and every sect, and all and sundry are allowed to live freely according to their creed." In 2021, UNESCO designated "Quanzhou, Emporium of the World," as a world heritage site, and the city is now the hub of the Belt and Road Initiative, the 21st Century Silk Road, which was inspired by ancient Quanzhou.
Since the greenhouse effect emerged as a predictable threat, necessitating the evalu ation of its future impact on the environment in the various parts of the globe, interest in the climate changes during the Holocene has gained momentum. The background can be summarized by the sentence: The past is a key to the future. As a matter of fact, this sentence is in the opposite direction, on the dimension of time, to the principle adopted by the founders of the science of geology. They proposed that geological processes in the present should be used as a key for understanding the past. Another reason for the interest in the history of the climate of the Holocene can be described as the renaissance of a modified deterministic approach to the inter relation between physical and human geography. This relates in the first place to the fact that various investigations, especially as carried out by Hubert Lamb, showed that the sequence of climate changes previously suggested by Blytt and Sernander for Europe and adopted by most Holocene climatologists was far too general, and that there were more climate changes during recent history than previously taken account of. In the second place it was found out that these changes had had an impact on the history of human communities. Thus, one can conclude that once the taboo on geographical determinism (i. e."
New medical technologies are increasingly at the centre of novel
transformations in the human and social body. Whilst reproduction,
health, ageing and dying have long been areas for technical
intervention, the emergence of molecular biology and information
technology raise far-reaching political, social and subjective
questions. "New Medical Technologies and Society" provides a critical
introduction to the role and cultural significance of technological
innovation in redefining the boundaries of medicine and the body,
tracing this process through the figure of "the lifecourse."
Drawing on approaches from sociology and Science and Technology
Studies, the authors explore key issues, theories and debates at
the junctures of bodies and medicine. In a style that is both
innovative and challenging, Nik Brown and Andrew Webster open up an
important examination of new medical technologies not only for
those directly engaged, but for a wider audience interested in the
ways in which contemporary technologies can be interrogated through
core sociological inquiry. They argue that, whilst many
technologies emerge from and extend long-standing frameworks of
medical treatment, genuinely novel and radical challenges to our
interpretations of embodiment are emerging. The book will be essential reading for both students and scholars of the sociology of science and technology, medical sociology, social theory, genetics and informatics.
This open access book explores the past and present of Quanzhou (Zayton) and the rich diversity and tolerance that kindled Quanzhou's innovativeness and helped it prosper both commercially and culturally-values that are today being embraced by China's global trade partners. Quanzhou (Zayton), Marco Polo's port of departure and Columbus' goal in China, was not only the start of the Maritime Silk Road and the Middle Age's greatest port but also centuries ahead of its time in its tolerance and diversity. The fabled "City of Light" had 7 mosques for its 40,000 Muslims, some of whom served in government, as well as 3 Franciscan cathedrals funded in part by the emperor, Jewish synagogues, and centers for Nestorian Christians, Hindus, Taoists, Manicheans, Jains, etc. As Franciscan Bishop Andrew of Perugia wrote in 1322, "Tis a fact that in this vast empire, there are people of every nation under heaven, and every sect, and all and sundry are allowed to live freely according to their creed." In 2021, UNESCO designated "Quanzhou, Emporium of the World," as a world heritage site, and the city is now the hub of the Belt and Road Initiative, the 21st Century Silk Road, which was inspired by ancient Quanzhou.
This open access book presents the findings of the author's 3 decades of studying China's evolving anti-poverty strategies. It argues that much of the billions that nations spend yearly on economic aid is used inefficiently or to treat the symptoms but not the root causes of poverty. China, however, has evolved an effective sustainable alternative by providing the means for self-reliance to not only relieve economic poverty but also poverty of spirit. As a result, the success of China's historic war on poverty has been due not only to top-down visionary leadership but also to the bottom-up initiatives of an empowered populace unswervingly united in ending poverty. From 1993 to 2019, the author drove over 200,000 km around China and interviewed hundreds of people from all walks of life as he explored the evolution of China's anti-poverty strategies from simplistic aid and redistribution, which often engendered dependency and poverty of spirit. Over time, the philosophy shifted to empowerment by fostering self-reliance-or as Chinese put it, "blood production rather than blood transfusion." The primary method of empowerment was to provide modern infrastructure, "Roads first, then riches," so rural dwellers in remote Inner Mongolia or the Himalayan heights of Tibet had the same access to markets, jobs and internet for e-commerce as their urban counterparts. People who seized the opportunities and prospered first then used their newfound wealth and experience to help others. The stories in this book include a Tibetan entrepreneur whose family was impoverished in spite of 300 years of service to the Panchen Lama, or the farm girl with 4 years of education who now has several international schools, a biotechnology company and poverty alleviation projects across China, or the photographer who walked 40,000 km through deserts to chronicle the threat of desertification. Their tales underscore how diverse people across China helped make possible China's success in alleviating absolute poverty and why Chinese are now confident in achieving a "moderately prosperous society."
This open access book presents the findings of the author's 3 decades of studying China's evolving anti-poverty strategies. It argues that much of the billions that nations spend yearly on economic aid is used inefficiently or to treat the symptoms but not the root causes of poverty. China, however, has evolved an effective sustainable alternative by providing the means for self-reliance to not only relieve economic poverty but also poverty of spirit. As a result, the success of China's historic war on poverty has been due not only to top-down visionary leadership but also to the bottom-up initiatives of an empowered populace unswervingly united in ending poverty. From 1993 to 2019, the author drove over 200,000 km around China and interviewed hundreds of people from all walks of life as he explored the evolution of China's anti-poverty strategies from simplistic aid and redistribution, which often engendered dependency and poverty of spirit. Over time, the philosophy shifted to empowerment by fostering self-reliance-or as Chinese put it, "blood production rather than blood transfusion." The primary method of empowerment was to provide modern infrastructure, "Roads first, then riches," so rural dwellers in remote Inner Mongolia or the Himalayan heights of Tibet had the same access to markets, jobs and internet for e-commerce as their urban counterparts. People who seized the opportunities and prospered first then used their newfound wealth and experience to help others. The stories in this book include a Tibetan entrepreneur whose family was impoverished in spite of 300 years of service to the Panchen Lama, or the farm girl with 4 years of education who now has several international schools, a biotechnology company and poverty alleviation projects across China, or the photographer who walked 40,000 km through deserts to chronicle the threat of desertification. Their tales underscore how diverse people across China helped make possible China's success in alleviating absolute poverty and why Chinese are now confident in achieving a "moderately prosperous society."
This open access book explores the historical, cultural and philosophical contexts that have made anti-poverty the core of Chinese society since Liberation in 1949, and why poverty alleviation measures evolved from the simplistic aid of the 1950s to Xi Jinping's precision poverty alleviation and its goal of eliminating absolute poverty by 2020. The book also addresses the implications of China's experience for other developing nations tackling not only poverty but such issues as pandemics, rampant urbanization and desertification exacerbated by global warming. The first of three parts draws upon interviews of rural and urban Chinese from diverse backgrounds and local and national leaders. These interviews, conducted in even the remotest areas of the country, offer candid insights into the challenges that have forced China to continually evolve its programs to resolve even the most intractable cases of poverty. The second part explores the historic, cultural and philosophical roots of old China's meritocratic government and how its ancient Chinese ethics have led to modern Chinese socialism's stance that "poverty amidst plenty is immoral". Dr. Huang Chengwei, one of China's foremost anti-poverty experts, explains the challenges faced at each stage as China's anti-poverty measures evolved over 70 years to emphasize "enablement" over "aid" and to foster bottom-up initiative and entrepreneurialism, culminating in Xi Jinping's precision poverty alleviation. The book also addresses why national economic development alone cannot reduce poverty; poverty alleviation programs must be people-centered, with measurable and accountable practices that reach even to household level, which China has done with its "First Secretary" program. The third part explores the potential for adopting China's practices in other nations, including the potential for replicating China's successes in developing countries through such measures as the Belt and Road Initiative. This book also addresses prevalent misperceptions about China's growing global presence and why other developing nations must address historic, systemic causes of poverty and inequity before they can undertake sustainable poverty alleviation measures of their own. |
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