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Scaffold Hopping in Medicinal Chemistry (Hardcover) Loot Price: R3,113
Discovery Miles 31 130
You Save: R761 (20%)
Scaffold Hopping in Medicinal Chemistry (Hardcover): N. Brown

Scaffold Hopping in Medicinal Chemistry (Hardcover)

N. Brown

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List price R3,874 Loot Price R3,113 Discovery Miles 31 130 | Repayment Terms: R292 pm x 12* You Save R761 (20%)

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This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects. The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part describes the most common tools and methods for scaffold hopping, whether topological, shape-based or structure-based. Methods such as CATS, Feature Trees, Feature Point Pharmacophores (FEPOPS), and SkelGen are discussed among many others. The final part contains three fully documented real-world examples of successful drug development projects by scaffold hopping that illustrate the benefits of the approach for medicinal chemistry. While most of the case studies are taken from medicinal chemistry, chemical and structural biologists will also benefit greatly from the insights presented here.

General

Imprint: Wiley-VCH Verlag GmbH
Country of origin: Germany
Release date: December 2013
First published: 2014
Authors: N. Brown
Dimensions: 247 x 175 x 22mm (L x W x T)
Format: Hardcover
Pages: 328
ISBN-13: 978-3-527-33364-6
Categories: Books > Science & Mathematics > Chemistry > General
Books > Professional & Technical > Industrial chemistry & manufacturing technologies > Industrial chemistry > Pharmaceutical technology
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LSN: 3-527-33364-9
Barcode: 9783527333646

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