The chemokines family of small proteins are involved in numerous b- logical processes ranging from hematopoiesis, angiogenesis, and basal l- kocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage, and bacterial or viral infection. Chemokines exert their effects through a family of seven G-protein coupled transmembrane receptors. Worldwide interest in the chemokine field surged dramatically early in 1996, with the finding that certain chemokine receptors were the elusive coreceptors, required along with CD4, for HIV infection. Today, though over 40 human chemokines have been described, the n- ber of chemokine receptors lags behind-only 17 human chemokine receptors have been identified so far. What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors. Yet in spite of the apparent redundancy in chemokine/chemokine rec- tor interactions, it is clear that in vivo, spatial, temporal, and indeed cell- and tissue-specific expression of both chemokines and their receptors are imp- tant factors in determining the precise nature of cellular infiltrates in phy- ological and pathological processes.

"The Atmosphere and Ocean" is a fully revised and updated student friendly physical introduction to the atmosphere and ocean. Now in its Third Edition, the book continues to provide students with an accessible description of the atmosphere and ocean with emphasis on their physical properties and inter-dependence.

Clearly structured throughout, the book demonstrates that the atmosphere and ocean are both subject to the influence of the earth's rotation and therefore they have a common dynamical basis. The author clearly demonstrates the fundamental differences between the two environments and provides the reader with a much better understanding of the atmosphere and the ocean and an appreciation of their closest interactive relationship. There have been many developments in the field over the past ten years and this latest edition of a highly successful textbook brings together new material on the ocean-atmosphere system and climate, the observed circulation of the atmosphere and ocean and radiation in the atmosphere and ocean.Fully revised and updated 3rd Edition of student friendly physical introduction to the atmosphere and ocean. Now includes new chapters on observed circulation of the atmosphere and ocean, energy flows in the ocean atmosphere system, modeling the ocean and atmosphere, the ocean atmosphere system and climate. Well structured and written in an authoritative yet accessible style suitable for 2nd and 3rd year students taking courses in meteorology, oceanography and related Earth Sciences or as an introduction for graduate students. Emphasis placed on physical properties and inter-dependence of the ocean and climate. Part of the RMetS (Royal Meteorological Society) book series, "Advancing Weather and Climate Science"

The chemokines family of small proteins are involved in numerous b- logical processes ranging from hematopoiesis, angiogenesis, and basal l- kocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage, and bacterial or viral infection. Chemokines exert their effects through a family of seven G-protein coupled transmembrane receptors. Worldwide interest in the chemokine field surged dramatically early in 1996, with the finding that certain chemokine receptors were the elusive coreceptors, required along with CD4, for HIV infection. Today, though over 40 human chemokines have been described, the n- ber of chemokine receptors lags behind-only 17 human chemokine receptors have been identified so far. What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors. Yet in spite of the apparent redundancy in chemokine/chemokine rec- tor interactions, it is clear that in vivo, spatial, temporal, and indeed cell- and tissue-specific expression of both chemokines and their receptors are imp- tant factors in determining the precise nature of cellular infiltrates in phy- ological and pathological processes.

"The Atmosphere and Ocean" is a fully revised and updated student friendly physical introduction to the atmosphere and ocean. Now in its Third Edition, the book continues to provide students with an accessible description of the atmosphere and ocean with emphasis on their physical properties and inter-dependence.

Clearly structured throughout, the book demonstrates that the atmosphere and ocean are both subject to the influence of the earth's rotation and therefore they have a common dynamical basis. The author clearly demonstrates the fundamental differences between the two environments and provides the reader with a much better understanding of the atmosphere and the ocean and an appreciation of their closest interactive relationship. There have been many developments in the field over the past ten years and this latest edition of a highly successful textbook brings together new material on the ocean-atmosphere system and climate, the observed circulation of the atmosphere and ocean and radiation in the atmosphere and ocean.Fully revised and updated 3rd Edition of student friendly physical introduction to the atmosphere and ocean. Now includes new chapters on observed circulation of the atmosphere and ocean, energy flows in the ocean atmosphere system, modeling the ocean and atmosphere, the ocean atmosphere system and climate. Well structured and written in an authoritative yet accessible style suitable for 2nd and 3rd year students taking courses in meteorology, oceanography and related Earth Sciences or as an introduction for graduate students. Emphasis placed on physical properties and inter-dependence of the ocean and climate. Part of the RMetS (Royal Meteorological Society) book series, "Advancing Weather and Climate Science"