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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Biochemical immunology
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Chemokine Protocols (Hardcover, 2000 ed.)
Loot Price: R3,095
Discovery Miles 30 950
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Chemokine Protocols (Hardcover, 2000 ed.)
Series: Methods in Molecular Biology, 138
Expected to ship within 10 - 15 working days
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The chemokines family of small proteins are involved in numerous b-
logical processes ranging from hematopoiesis, angiogenesis, and
basal l- kocyte trafficking to the extravasation and tissue
infiltration of leukocytes in response to inflammatory agents,
tissue damage, and bacterial or viral infection. Chemokines exert
their effects through a family of seven G-protein coupled
transmembrane receptors. Worldwide interest in the chemokine field
surged dramatically early in 1996, with the finding that certain
chemokine receptors were the elusive coreceptors, required along
with CD4, for HIV infection. Today, though over 40 human chemokines
have been described, the n- ber of chemokine receptors lags
behind-only 17 human chemokine receptors have been identified so
far. What has emerged over the years is that most chemokine
receptors bind several distinct ligands, and indeed the majority of
chemokines are able to bind to multiple chemokine receptors,
explaining to some extent the apparent disparity in the numbers of
chemokines and rec- tors. Yet in spite of the apparent redundancy
in chemokine/chemokine rec- tor interactions, it is clear that in
vivo, spatial, temporal, and indeed cell- and tissue-specific
expression of both chemokines and their receptors are imp- tant
factors in determining the precise nature of cellular infiltrates
in phy- ological and pathological processes.
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