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One of the promising approaches to enhance salt tolerance in crop
plants is the proper use of plant growth regulators. The presented
work is an effort to investigate the ameliorative role of
5-aminolevulinic acid (ALA) in oilseed rape plants grown under
salinity conditions. Chapter 1 of this monograph is a brief
introduction about oilseed rape (Brassica napus L.), salinity
associated problems and strategies to tackle salinity as well as
study's objectives. Chapter 2 highlights the previous studies and
achievements regarding the salinity stress and its interference
with the different physiological aspects of plants particularly
Brassica species as well as ameliorating role of 5-aminolevulinic
acid to combat stress conditions. Chapters 3 focus on how
5-aminolevulinic acid ameliorates salinity induced metabolic, water
related and biochemical changes. Chapter 4 describes the role of
5-aminolevulinic acid regarding photosynthetic gas exchange
capacity and ion uptake under salinity stress. Chapter 5 highlights
the ultra-structural modifications induced by salinity and
5-aminolevulinic acid in oilseed rape plants. Chapter 6&7
presents our major findings and references.
The production of recombinant biopharmaceuticals with antiviral and
antiproliferative properties is one of the major aims of advanced
genetic engineering. Interferon alpha 2b belongs to the class of
recombinant therapeutics which is equally effective against viral
infections and carcinomas. Recombinant human IFN 2b is widely used
FDA approved protein drug with global sale level is expected to
reach up to 5.8 billion US dollars by 2010 due to its increased
demand as a result of high prevalence of hepatitis infections and
carcinomas in developed as well as developing countries including
Pakistan. In the current research a process was developed for the
production of this recombinant interferon alpha 2b drug by adopting
advanced molecular and biochemical strategies. Intragene
modifications at specific amino acids were also made to produce
antiviral gene sequences with improved antiviral properties. Human
interferon alpha 2b gene analysis was also established in blood
cancers (AML and ALL) in order to find out mutations of clinical
significance in theses cancers.
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