The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered. It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.

From 1837 to 1861 Thoreau kept a Journal that began as a conventional record of ideas, grew into a writer's notebook, and eventually became the principal imaginative work of his career. The source of much of his published writing, the Journal is also a record of both his interior life and his monumental studies of the natural history of his native Concord, Massachusetts. In contrast to earlier editions, the Princeton Edition reproduces the Journal in its original and complete form, in a reading text that is free of editorial interpolations but keyed to a comprehensive scholarly apparatus.

Despite activities as time-consuming and varied as urveying for the town of Concord and helping a fugitive slave escape to Canada, Thoreau wrote nearly eight hundred manuscript pages in his Journal during the eight months covered by this volume. Confirmed in his vocation as a natural historian, he began to compile the richly detailed records of Concord's woods, fields, and streams that would occupy him for the rest of his life, and he consciously shaped the Journal to reflect his new aims as a writer. He also began major revisions of his "Walden" that would lead to its publication in 1854.

From 1837 to 1861, Henry D. Thoreau kept a Journal that would become the principal imaginative work of his career. The source of much of his published writing, the Journal is also a record of his interior life and of his monumental studies of the natural history of his native Concord, Massachusetts. Unlike earlier editions, the Princeton edition reproduces Thoreau's Journal in its original and complete form, in a text free of editorial interpolations and keyed to a comprehensive scholarly apparatus.

This seventh volume of the Journal is edited from the 454-page manuscript that Thoreau kept from August 19, 1853, through February 12, 1854. During the six months covered here, Thoreau continued to add to his store of observations about local animals, plants, and weather. Most of the Journal is dedicated to describing natural phenomena, such as changes in leaf color and the ripening of berries, in the context of seasonal cycles. His observations create a detailed portrait of Concord and the surrounding areas that will be of interest to ecologists and others who study phenological patterns and variations. In addition, Thoreau integrates these observations with ethical reflections about living in harmony with nature, following the model of the Roman agricultural writers. The volume also includes Thoreau's account of a September 1853 trip to the Maine woods that appeared in 1858 as "Chesuncook"; the draft is published here for the first time.