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Provided here is a comprehensive examination of the basic and
clinical condition of three innovative and promising approaches to
cancer therapy, which may support or even substitute chemotherapy:
differentiation, immunomodulation, and inhibition of angiogenesis.
Differentiation shouldnormalize neoplastic cells and make them
compatible with the host. Its feasibility with retinoids,
interferons, chemotherapeutic and other agents is discussed.
Modulation by biological agents, cytotoxic effector cells and drugs
is considered in attempts to boost endogenous antitumour defenses
and/or to render neoplastic cells more susceptible to the immune
attack of the host. Finally, the important aspect of interfering
with tumour blood vessel development and function is taken into
account. Consideringthe importance that chemotherapy has in cancer
treatment and in view of a more and more integrated strategy, the
relationship between the aforementioned approaches and
chemotherapeutic agents and chemoresistance is treated in detail.
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