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This is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs. It includes coverage of basic biostatistics for the clinical trialist, and fundamental concepts in clinical pharmacology.
Cutting-edge investigators review the current status of the entire
field, from the biology of MMPs through the current clinical
studies. The authors include many leading scientists from
pharmaceutical companies who present all the latest concepts and
results on the preferred design strategies for MMP inhibitors,
their molecular mechanisms, and their substrates. In addition, they
fully describe their personal research on specific MMP inhibitors,
detailing vanguard design strategies, their in vitro activity, the
outcome of animal model studies and, where available, their
toxicology, safety, efficacy in human clinical trials.
This is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs. It includes coverage of basic biostatistics for the clinical trialist, and fundamental concepts in clinical pharmacology.
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