Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig's Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials.

A state-of-the-art guide to evolving functional neurosurgery approaches from world-renowned innovators Functional neurosurgery focuses on improving the lives of patients with epilepsy, movement disorders, pain, and psychiatric illnesses. In recent years, approaches ranging from open surgery to minimally invasive techniques have been leveraged to improve daily functioning and quality of life in people struggling with painful, highly disruptive, and/or treatment-resistant symptoms. These approaches focus on reducing or eliminating seizures, alleviating pain, decreasing abnormal movements or lessening debilitating symptoms associated with specific psychiatric disorders. Neurosurgical Operative Atlas: Functional Neurosurgery, Third Edition, by renowned functional neurosurgeons Robert Gross, Nicholas Boulis, and esteemed contributors reflects the latest advances in functional and stereotactic neurosurgical approaches. The entire atlas has been streamlined and updated with new content, including the use of stereotactic surgery to treat obsessive compulsive disorder, Tourette syndrome, and major depression. Key Highlights A full spectrum of epilepsy treatment techniques, including intracranial monitoring with stereo-electroencephalography, selective amygdalohippocampectomy, MRI-guided stereotactic laser ablation, vagus nerve stimulation, and more Deep brain stimulation (DBS) for Parkinson's disease, tremor, dystonia, epilepsy and medically intractable pain syndromes, with in-depth implantation guidance The use of neurosurgical and interventional techniques to treat pain including percutaneous ablation, peripheral nerve stimulation, spinal cord and motor cortex stimulators, and pumps More than 300 high quality color illustrations detail anatomy and surgical procedures This is the ultimate guide on functional neurosurgery for managing a wide range of incapacitating neurological conditions. Neurosurgical residents, fellows, and veteran neurosurgeons specializing in this rapidly evolving subspecialty will find this state-of-the-art book invaluable — reading it cover to cover will ultimately benefit patients. Series description The American Association of Neurological Surgeons and Thieme have collaborated to produce the third edition of the acclaimed Neurosurgical Operative Atlas series. Edited by leading experts in the field, the series covers the entire spectrum of neurosurgery in five volumes. In addition to Functional Neurosurgery, the series also features: Spine and Peripheral Nerves, edited by Christopher E. Wolfa and Daniel K. Resnick Vascular Neurosurgery, edited by R. Loch Macdonald Neuro-Oncology, edited by Behnam Badie and Mike Y. Chen Pediatric Neurosurgery, edited by James Tait Goodrich and Robert F. Keating