In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.

In vivo magnetic resonance spectrosopy (MRS) is increasingly being used in the clinical setting, particularly for neurological disorders. Clinical MR Spectroscopy - Techniques and Applications explains both the underlying physical principles of MRS and provides a perceptive review of clinical MRS applications. Topics covered include an introduction to MRS physics, information content of spectra from different organ systems, spectral analysis methods, recommended protocols and localization techniques, and normal age- and region-related spectral variations in the brain. Clinical applications in the brain are discussed for brain tumors, hypoxic and ischemic injury, infectious, inflammatory and demyelinating diseases, epilepsy, neurodegenerative disorders, trauma and metabolic diseases. Outside of the brain, techniques and applications are discussed for MRS in the musculosketal system, breast and prostate. Written by leading MRS experts, this is an invaluable guide for anyone interested in in vivo MRS, including radiologists, neurologists, neurosurgeons, oncologists and medical researchers.