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Multipotent mesenchymal stem cells (MSCs) are a heterogeneous
population of cells which reside in a variety of tissues. They
differentiate into several mesodermal lineages, secrete a multitude
of trophic factors and contribute to tissue homeostasis. MSCs are
able to exert immunosuppressive activities by interfering with
inflammatory cytokine production and with T- and B-cell
proliferation. These immunomodulating properties make MSCs
promising candidates for the treatment of chronic inflammatory and
autoimmune disorders. There are, however, certain caveats involved
including inappropriate migration of cells in the body, immune
rejection, tumor formation, or graft versus host disease (GvHD).
This book investigates the current state of the MSC-dependent
therapy of chronic inflammatory disorders and autoimmune diseases.
Among the covered topics are GvHD, chronic kidney, liver and lung
disease, ischemic heart and inflammatory bowel disease, diabetes,
osteoarthritis, various rheumatic and neurological disorders and,
lastly, tumors and solid organ transplantations. This book also
questions the immunoprivileged status of MSCs, discusses the
therapeutic role of MSCs in experimental animal disease models and
their translation to the corresponding human disorders, envisions a
role for MSCs in tumor interventions and, lastly, describes a
systems biology approach for stem cells and inflammation.
Immunometabolism has emerged as an intersectional crossroad between
metabolism and immune response. Over the past decade, it has become
clear that most - if not all - immune cell functions are not
separated from cellular metabolism. Although seminal works have
addressed the metabolic fate of immune cells during differentiation
and function, the physiological status of a given tissue is also
dependent on the cell metabolism. The dialogue between immune cells
and their microenvironment can also modulate cellular metabolism,
which can trigger the onset and progression of a multitude of
inflammation-mediated diseases. Thus, uncovering the specific
characteristics of the metabolism in different immune cells types
and in different conditions, can shed light into the molecular
mechanisms of disease and help develop new drugs and therapeutic
strategies to treat immune diseases. The edited volume Essentials
aspects of Immunometabolism will give the readers a broad view on
how metabolic pathways can influence many types of immune cells
during activation, differentiation and function, in health and
disease. Of note, the structure of the book was created thinking
not only on the experienced immunologist but also on undergraduate
and graduate students, physicians, and all members of the
scientific community interested in this exciting field of research.
Immunometabolism has emerged as an intersectional crossroad between
metabolism and immune response. Over the past decade, it has become
clear that most - if not all - immune cell functions are not
separated from cellular metabolism. Although seminal works have
addressed the metabolic fate of immune cells during differentiation
and function, the physiological status of a given tissue is also
dependent on the cell metabolism. The dialogue between immune cells
and their microenvironment can also modulate cellular metabolism,
which can trigger the onset and progression of a multitude of
inflammation-mediated diseases. Thus, uncovering the specific
characteristics of the metabolism in different immune cells types
and in different conditions, can shed light into the molecular
mechanisms of disease and help develop new drugs and therapeutic
strategies to treat immune diseases. The edited volume Essentials
aspects of Immunometabolism will give the readers a broad view on
how metabolic pathways can influence many types of immune cells
during activation, differentiation and function, in health and
disease. Of note, the structure of the book was created thinking
not only on the experienced immunologist but also on undergraduate
and graduate students, physicians, and all members of the
scientific community interested in this exciting field of research.
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Markus Oehlen - 2009-2019 (Hardcover)
Bärbel Grässlin; Text written by Gregor Jansen, Erich Gantzert-Castrillo, Niels Olsen, Matthew Bowman, …
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R1,363
R1,131
Discovery Miles 11 310
Save R232 (17%)
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Ships in 10 - 15 working days
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Markus Oehlen (*1956) is one of Germany's most unmistakable
painters. As an anarchic pictorial inventor, since the 1980s he has
revolted against any visual convention and aesthetic convenience.
Due to his integration of digital techniques and the contemporary
reservoir of images, he creates stunningly hybrid paintings.
Collage-like fragments of art history and popular culture interfere
with each other. Abstraction and figuration swiftly blend into one
another. With the utmost freedom, Oehlen expands the possibilities
of today's painting in his both daring and calculated pictorial
experiments.
Cloud '68-Paper Voice pays homage to the European radical movements
in architecture that flourished between the 1950s and 1970s
producing a wide range of experimental expression. From the
personal collection of the Chilean architect Smiljan Radic, a
selection of 173 graphic pieces-lithographs, drawings, original
etchings, and ephemera-will show the horizon of meaning of the
diverse architectural approaches from those years: works by
Constant, Guy Debord, Asger Jorn, Haus-Rucker-Co, Archigram,
Utopie, and Superstudio, among others, will meet in 33 panels that
recall Aby Warburg's "Mnemosyne Atlas." The publication is
complemented by a "Wunderkammer" of interview fragments by the
critic and curator Hans Ulrich Obrist, who interviewed the
protagonists of said architecture.
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Sylvie Fleury - Double Positive (Paperback)
Sylvie Fleury; Edited by Fredi Fischli; Text written by Fredi Fischli; Edited by Niels Olsen; Text written by Niels Olsen, …
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R653
Discovery Miles 6 530
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Ships in 12 - 17 working days
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