Stem Cell-Dependent Therapies - Mesenchymal Stem Cells in Chronic Inflammatory Disorders (Hardcover)

Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

General

Imprint:	De Gruyter
Country of origin:	Germany
Release date:	October 2013
First published:	2013
Editors:	Gerhard Gross • Thomas Haupl
Contributors:	Graca Almeida-Porada • Leo Buhler • Niels Olsen Saraiva Camara • Pierre Charbord • Yves A Declerck • James E. Dennis • Carmen Gonelle-Gispert • Jens Kastrup
Dimensions:	240 x 170mm (L x W)
Format:	Hardcover - Cloth over boards
Pages:	426
ISBN-13:	978-3-11-029826-0
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > General issues > Medical equipment & techniques > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology > General
LSN:	3-11-029826-0
Barcode:	9783110298260

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