Facilitates the selection of appropriate procedures when using SPE to clean up samples, extract, and concentrate analytes or eliminate interferring substances in sample analyses. This comprehensive reference/text demonstrates the relationship of the basic theory of solid-phase extraction (SPE) to chromatography-illustrating how SPE techniques significantly contribute to the preparation of samples for a wide variety of analytical techniques, including gas chromatography, mass spectrometry, and high-performance liquid chromatographic analyses. Provides step-by-step details on the applications of SPE to environmental matrices, broad-spectrum drug screening, veterinary drug abuse, pharmaceutical drug development, biological samples, and high-throughput screening Written by world-renowned experts in the field, Solid-Phase Extraction thoroughly covers digital chromatography, the basic elements of SPE, capacity and selectivity, and the mechanisms of adsorption and desorption nonpolar, polar, and ion-exchange extraction mechanisms, as well as complexation, chelation, and covalent retention actual vs. ideal performance and predictive SPE, as well as expert systems using and eliminating secondary interactions and mixed-mode SPE preparing and handling biological fluids, particulates, solid and air samples by SPE, including problem components in a sample matrix creating affinity sorbents and the properties and uses of affinity SPE automation approaches, techniques for automated method development, off-line solid extraction, and on-line SPE complementary use of SPE and supercritical fluid extraction and more Containing helpful reference charts, tables of solvent properties, selectivities, molecular acid/base properties, and more, Solid-Phase Extraction is an essential, on-the-job reference for analytical, environmental, synthetic organic, and medicinal chemists and biochemists; and toxicologists; and an ideal textbook for upper-level undergradua