Facilitates the selection of appropriate procedures when using SPE
to clean up samples, extract, and concentrate analytes or eliminate
interferring substances in sample analyses. This comprehensive
reference/text demonstrates the relationship of the basic theory of
solid-phase extraction (SPE) to chromatography-illustrating how SPE
techniques significantly contribute to the preparation of samples
for a wide variety of analytical techniques, including gas
chromatography, mass spectrometry, and high-performance liquid
chromatographic analyses. Provides step-by-step details on the
applications of SPE to environmental matrices, broad-spectrum drug
screening, veterinary drug abuse, pharmaceutical drug development,
biological samples, and high-throughput screening Written by
world-renowned experts in the field, Solid-Phase Extraction
thoroughly covers digital chromatography, the basic elements of
SPE, capacity and selectivity, and the mechanisms of adsorption and
desorption nonpolar, polar, and ion-exchange extraction mechanisms,
as well as complexation, chelation, and covalent retention actual
vs. ideal performance and predictive SPE, as well as expert systems
using and eliminating secondary interactions and mixed-mode SPE
preparing and handling biological fluids, particulates, solid and
air samples by SPE, including problem components in a sample matrix
creating affinity sorbents and the properties and uses of affinity
SPE automation approaches, techniques for automated method
development, off-line solid extraction, and on-line SPE
complementary use of SPE and supercritical fluid extraction and
more Containing helpful reference charts, tables of solvent
properties, selectivities, molecular acid/base properties, and
more, Solid-Phase Extraction is an essential, on-the-job reference
for analytical, environmental, synthetic organic, and medicinal
chemists and biochemists; and toxicologists; and an ideal textbook
for upper-level undergradua
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