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This volume represents the proceedings of the 24th Mos bach
Colloquium on "Regulation of Transcription and Trans lation in
Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany,
under the auspices of the Gesellschaft fiir Biologische Chemie. To
the three of us (H. KERSTEN, P. KARLSON and myself) who were
commissioned with the invitation of speakers, it was a difficult
decision as to whether we should attempt to cover with some twenty
contributions as many aspects of this broad topic as possible, or
to sacrifice the intellectually perhaps more pleasing but more
specula tive concepts and to concentrate on a few aspects of gene
expression in reasonable detail. We unanimously decided on the
latter course, leaving such important and timely topics as for
example, hormone action, cyclic AMP and reverse transcription to
the proceedings of other symposia, and con centrating on the four
questions which are most basic to an understanding of the
mechanisms of transcription and trans lation and for which
fragmentary but nonetheless reliable experimental results have
become available within the last few years. These are the structure
of chromatin, the syn thesis of messenger RNA, the structure of the
active ribo some, and the role of initiation factors in protein
synthesis.
It is about 15 years since the first presentation on uteroglobin
was given to a group of developmental biologists, reproductive
physiologists, and geneticists who had gathered in November 1966 at
Konstanz (Germany). In the following decade so much knowledge was
accumulated that a special symposium seemed appropriate. This was
organized as a satellite symposium to the International Congress of
Endocrinology at Hamburg and brought together 50 scientists at
Aachen. These scientists, working in the field of pro teins and
steroids, in early pregnancy, recognized the impact of what had
been reported, and many of them later agreed to contribute to this
booN. and thus to present their research d, ta available until
December 1980. The present volume covers a relatively broad
spectrum of data and observations which shed some light on
preimplantational embryonic life and on the supports and obstacles
provided by the maternal organism with respect to final
accomplishment of normal im plantation and establishment of
pregnancy. The book will serve both as a textbook and as a
scientific dictionary for Ph.D. students, postdoctoral fellows and
advanced scientists working in this area. The course of early
pregnancy depends very much on a proper balance of steroid hor
mones, and the induction of protein synthesis by steroid hormones
is one of the well known fundamental processes in cellular
differentiation and embryonic development."
Das 18. Mosbacher Colloquium, uber welches der vorliegende Band
berichtet, war den Wirkungsmechanismen der Hormone gewidmet. Es war
die Idee der Veranstalter, in diesem Rahmen moglichst viele Aspekte
des Problems zu zeigen; eine enzyklo- padische Vollstandigkeit
hinsichtlich der zahlreichen Hormone wurde nicht angestrebt. Das
ware bei der beschrankten Zeit auch unmoglich gewesen. Einen kurzen
Uberblick uber den behandelten Themenkreis und den
wissenschaftlichen Ertrag des Colloquiums habe ich im SchluBwort
gegeben. Sinn eines Colloquiums ist das Gesprach, die Diskussion;
der Vortrag solI nur die Basis dazu liefern. In diesem Sinne haben
wir auch im vorliegenden Band der Diskussion einen breiten Raum
eingeraumt, und ich glaube, daB manche dieser Diskussionsbemer-
kungen die Vortrage erheblich erganzen und vertiefen. Die
Organisation der Veranstaltung lag weitgehend in den Randen von
Herrn Professor Dr. AUHAGEN. Die Tonbandaufnah- men der Diskussion,
die fur die schriftliche Fixierung der Dis- kussion von besonderer
Bedeutung waren, wurden in technisch Herrn Dr. WINTER, Stuttgart,
besorgt; hervorragender Weise von die hohe Qualitat dieser
Aufzeichnungen hat meine Arbeit als Herausgeber sehr erleichtert,
und ich mochte Herrn Dr. WINTER deshalb auch an dieser Stelle
danken. - Weiterhin gilt unser aller Dank den Vortragenden sowie
den Diskussionsrednern, die zum Gelingen des Colloquiums
beigetragen haben, insbesondere auch unseren Gasten aus dem
europaischen Ausland und den USA.
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