Serotonin (5-hydroxytryptamine, often cited as 5-HT) is one of the major excitatory neurotransmitter, and the serotonergic system is one of the best studied and understood transmitter systems. It is crucially involved in the organization of virtually all behaviours and in the regulation of emotion and mood. Alterations in the serotonergic system, induced by e.g. learning or pathological processes, underlie behavioural plasticity and changes in mood, which can finally results in abnormal behaviour and psychiatric conditions. Not surprisingly, the serotonergic system and its functional components appear to be targets for a multitude of pharmacological treatments - examples of very successful drugs targeting the serotoninergic system include Prozac and Zoloft.
The last decades of research have not only fundamentally expanded our view on serotonin but also revealed in much more detail an astonishing complexity of this system, which comprises a multitude of receptors and signalling pathways. A detailed view on its role in basal, but also complex, behaviours emerged, and, was presented in a number of single review articles. Although much is known now, the serotonergic system is still a fast growing field of research contributing to our present understanding of the brains function during normal and disturbed behaviour.
This handbook aims towards a detailed and comprehensive overview over the many facets of behavioural serotonin research. As such, it will provide the most up to date and thorough reading concerning the serotonergic systems control of behaviour and mood in animals and humans. The goal is to create a systematic overview and first hand reference that can be used by students and scholars alike in the fields of genetics, anatomy, pharmacology, physiology, behavioural neuroscience, pathology, and psychiatry. The chapters in this book will be written by leading scientists in this field. Most of them have already written excellent reviews in their field of expertise.
The book is divided in 4 sections. After an historical introduction, illustrating the growth of ideas about serotonin function in behaviour of the last forty years, section A will focus on the functional anatomy of the serotonergic system. Section B provides a review of the neurophysiology of the serotonergic system and its single components. In section C the involvement of serotonin in behavioural organization will be discussed in great detail, while section D deals with the role of serotonin in behavioural pathologies and psychiatric disorders.

* The first handbook broadly discussing the behavioral neurobiology of the serotonorgic transmitter system
* Co-edited by one of the pioneers and opinion leaders of the past decades, Barry Jacobs (Princeton), with an international list (10 countries) of highly regarded contributors providing over 50 chapters, and including the leaders in the field in number of articles and citations: K. P. Lesch, T. Sharp, A. Caspi, P. Blier, G.K. Aghajanian, E. C. Azmitia, and others
* The only integrated and complete resource on the market containing the best information integrating international research, providing a global perspective to an international community.
* Of great value not only for researchers and experts, but also for students and clinicians as a background reference.

The essays in this collection seek to reflect on global governance and to provide a better critical understanding of the various practices that fall under its rubric. The first part challenges the concept of global governance, the second part focuses on organizational and institutional aspects, and the last part examines the rule systems implemented by global governance practices. The vocabulary of (global) governance has become a serious contender to imagine world order in the post cold war world. Using different strategies of critique, the contributors argue that global governance denotes a political vocabulary where acts of definition themselves are political moves.

Drugs in professional sports. Today''s news? Not to the authors who take you behind the scenes into the backrooms, the board rooms and the high perches of politics where the quest for a state''s profit often outweighs giving the public a fair return for their loyalty and support. This is not your average sports story. It delves into the experiences of two people who defied fierce opposition and personal threat to do the right thing in the management of Thoroughbred Racing and Professional Hockey and in the evaluating and negotiating of Pro Baseball and Football teams. We are not born with integrity. It is the product of our pasts, how we meet life''s challenges, and in our case, the deep faith which gave us the courage to confront our enemies and realize our goals. Biographical in form, you will relive the author''s early years and travel the diverse paths their lives took. You may often ponder how this successful partnership evolved, Man/Woman. Catholic/Jew. Poor Boy/Rich Girl. New England Newspaper columnist/ New York entertainment writer. Running sports facilities, hosting thousands of patrons daily at an arena, stadium or paying field was a unique challenge. Vin Bartimo had the prime responsibility for the action, Roz Muller was the champion of the fans. Together, they made winners of losing entities, shared their largesse with the communities in which they operated and gave the public what they wanted and deserved.

Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood.

In this original work of psychoanalytic theory, John Muller explores the formative power of signs and their impact on the mind, the body and subjectivity, giving special attention to work of the French psychoanalyst Jacques Lacan and the American philosopher Charles Sanders Peirce. Muller explores how Lacan's way of understanding experience through three dimensions--the real, the imaginary and the symbolic--can be useful both for thinking about cultural phenomena and for understanding the complexities involved in treating psychotic patients. Muller develops Lacan's perspective gradually, presenting it as distinctive approaches to data from a variety of sources, such as cognitive, social and developmental psychology, literature, history, art, and psychoanalytic treatment.
The book's first four chapters present Muller's reading of selected data from child development research, psychology and linguistics, approximating a semiotic model of "normal" development. The following three chapters examine in a Lacanian framework the structural basis of psychotic stages as indicative of massive semiotic failure in development. The final chapters on human narcissism suggest reasons that "normal" development may be impossible.

This work explores the formative power of signs and their impact on the mind, the body and subjectivity, giving special attention to work of the French analyst Jacques Lacan and the American philosopher Charles Sanders Peirce.

This volume addresses itself to the ways in which the so-called 'new sciences of complexity' can deepen and broaden neurobiological and psychological theories of mind. Complexity theory has gained increasing attention over the past 20 years across diverse areas of inquiry, including mathematics, physics, economics, biology, and the social sciences. Complexity theory concerns itself with how nonlinear dynamical systems evolve and change over time and draws on research arising from chaos theory, self-organization, artificial intelligence and cellular automata, to name a few. This emerging discipline shows many points of convergence with psychological theory and practice, emphasizing that history is irreversible and discontinuous, that small early interventions can have large and unexpected later effects, that each life trajectory is unique yet patterned, that measurement error is not random and cannot be justifiably distributed equally across experimental conditions, that a system's collective and coordinated organization is emergent and often arises from simple components in interaction, and that change is more likely to emerge under conditions of optimal turbulence.

The work on Autonomic Road Transport Support (ARTS) presented here aims at meeting the challenge of engineering autonomic behavior in Intelligent Transportation Systems (ITS) by fusing research from the disciplines of traffic engineering and autonomic computing. Ideas and techniques from leading edge artificial intelligence research have been adapted for ITS over the last 30 years. Examples include adaptive control embedded in real time traffic control systems, heuristic algorithms (e.g. in SAT-NAV systems), image processing and computer vision (e.g. in automated surveillance interpretation). Autonomic computing which is inspired from the biological example of the body's autonomic nervous system is a more recent development. It allows for a more efficient management of heterogeneous distributed computing systems. In the area of computing, autonomic systems are endowed with a number of properties that are generally referred to as self-X properties, including self-configuration, self-healing, self-optimization, self-protection and more generally self-management. Some isolated examples of autonomic properties such as self-adaptation have found their way into ITS technology and have already proved beneficial. This edited volume provides a comprehensive introduction to Autonomic Road Transport Support (ARTS) and describes the development of ARTS systems. It starts out with the visions, opportunities and challenges, then presents the foundations of ARTS and the platforms and methods used and it closes with experiences from real-world applications and prototypes of emerging applications. This makes it suitable for researchers and practitioners in the fields of autonomic computing, traffic and transport management and engineering, AI, and software engineering. Graduate students will benefit from state-of-the-art description, the study of novel methods and the case studies provided.

This book constitutes the proceedings of the 12th German Conference on Multiagent System Technologies, MATES 2014, held in Stuttgart, Germany, in September 2014. The 9 full papers and 7 short papers included in this volume were carefully reviewed and selected from 31 submissions. The book also contains 2 invited talks. The papers are organized in topical sections named: mechanisms, negotiation, and game theory; multiagent planning, learning, and control; and multiagent systems engineering, modeling and simulation.

This book constitutes the thoroughly refereed and revised selected papers from the 9th International Workshop on Agents and Data Mining Interaction, ADMI 2013, held in Saint Paul, MN, USA in May 2013. The 10 papers presented in this volume were carefully selected for inclusion in the book and are organized in topical sections named agent mining and data mining.

The explosive growth of application areas such as electronic commerce, ent- prise resource planning and mobile computing has profoundly and irreversibly changed our views on software systems. Nowadays, software is to be based on open architectures that continuously change and evolve to accommodate new components and meet new requirements. Software must also operate on di?- ent platforms, without recompilation, and with minimal assumptions about its operating environment and its users. Furthermore, software must be robust and ] autonomous, capable of serving a naive user with a minimum of overhead and interference. Agent concepts hold great promise for responding to the new realities of software systems. They o?er higher-level abstractions and mechanisms which address issues such as knowledge representation and reasoning, communication, coordination, cooperation among heterogeneous and autonomous parties, p- ception, commitments, goals, beliefs, and intentions, all of which need conceptual modelling. On the one hand, the concrete implementation of these concepts can lead to advanced functionalities, e.g., in inference-based query answering, tra- action control, adaptive work?ows, brokering and integration of disparate inf- mation sources, and automated communication processes. On the other hand, their rich representational capabilities allow more faithful and ?exible treatments of complex organizational processes, leading to more e?ective requirements an- ysis and architectural/detailed design."

Zoogeography aims to explain the structure, function and history of the geo graphical ranges of animals. The absence or presence of a species in a given place has ecological as well as historical causes. It is therefore a mistake to suppose that reconstructing the phylogenetic connections of a taxon will by itself give a definite picture of how its range originated. A purely ecological interpretation of the range could be equally misleading if it did not take into account the population-genetic structure underlying the geographical range. Phylogenetic systematics, population genetics, autecology and synecology have all their own methods, none of which can be substituted for another, without which a range cannot be studied or interpreted. The present book covers only certain aspects of the wide field of zoogeo graphy. These are in the form in which they were crystallised in the course of innumerable discussions with my teachers, my colleagues at home and abroad and my fellow workers, postgraduates and students at Saarbriicken, as well as in the zoogeographical part of may basic lectures on biogeography for the year 1973-1974. The chief emphasis is laid on the genetic and ecological macro structure of the biosphere as an arena for range structures and range dynamics, on urban ecosystems, which have hitherto been grossly neglected, and on the most recent history of ranges (the dispersal centre concept). The marine and fresh-water biocycles, on the other hand, have been dealt only briefly."

In 1956 Jacques Lacan proposed an interpretation of Edgar Allan Poe's "Purloined Letter" that at once challenged literary theorists and revealed a radical new concept of psychoanalysis. Lacan's far reaching claims about language and truth provoked a vigorous critique by Jacques Derrida, whose essay in turn spawned further responses from other writers. "The Purloined Poe" brings Poe's story together with these readings to provide a structured exercise in the elaboration of text interpretation.

In This Volume dedicated to medieval canon law expert Kenneth Pennington, leading scholars from around the world discuss the contribution of medieval church law to the origins of the western legal tradition. The stellar cast assembled by editors Wolfgang P. Muller and Mary E. Sommar includes younger scholars as well as long-established specialists in the field. Muller's introduction provides the first comprehensive survey of investigative trends in the field in more than twenty years. Subdivided into four topical categories, the essays cover the entire range of the history of medieval canon law from the sixth to the sixteenth century. The first section concentrates on the canonical tradition before the advent of academic legal studies in the twelfth century. The second addresses the formation of canonistic theory. The third and fourth sections consider the intellectual exchanges between canon law and other fields of study, as well as the practical application of canons in day-to-day court proceedings. Though the twenty-seven essays included in this volume are quite diverse, taken together they provide an outstanding overview of the latest research and cutting-edge scholarship on the topic. Kenneth Pennington is Kelly-Quinn Professor of Ecclesiastical and Legal History at the Catholic University of America. He is the author of numerous works including Pope and Bishops: The Papal Monarchy in the Twelfth and Thirteenth Centuries and The Prince and the Law, 1200-1600: Sovereignty and Rights in the Western Legal Tradition, and is coeditor of the CUA Press series, History of Medieval Canon Law.

From the establishment of a coherent doctrine on sacramental marriage to the eve of the Reformation, late medieval church courts were used for marriage cases in a variety of ways. Ranging widely across Western Europe, including the Upper and Lower Rhine regions, England, Italy, Catalonia, and Castile, this study explores the stark discrepancies in practice between the North of Europe and the South. Wolfgang P. Muller draws attention to the existence of public penitential proceedings in the North and their absence in the South, and explains the difference in demand, as well as highlighting variations in how individuals obtained written documentation of their marital status. Integrating legal and theological perspectives on marriage with late medieval social history, Muller addresses critical questions around the relationship between the church and medieval marriage, and what this reveals about both institutions.

This book constitutes revised, selected, and invited papers from the 4th International Workshop on Engineering Multi-Agent Systems, EMAS 2016, held in Singapore, in May 2016, in conjunction with AAMAS. The 10 full papers presented in this volume were carefully reviewed and selected from 14 submissions. The book also contains 2 invited papers; extended versions of AAMAS 2016 demonstration abstracts. EMAS deals with MAS software engineering processes, methodologies and techniques; Programming languages for MAS; Formal methods and declarative technologies for the specification, validation and verification of MAS; and development tools.

This book constitutes the proceedings of the 13th German Conference on Multiagent System Technologies, MATES 2015, held in Cottbus, Germany, in September 2015. The 11 full papers papers presented together with 2 short papers, 1 invited paper and 4 extended abstracts of doctoral papers in this volume were carefully reviewed and selected from 27 submissions. The papers are organized in topical sections on MAS engineering, modeling, and simulation; smart things working together; and innovative and emerging applications of MAS.

The essays in this collection seek to reflect on global governance and to provide a better critical understanding of the various practices that fall under its rubric. The first part challenges the concept of global governance, the second part focuses on organizational and institutional aspects, and the last part examines the rule systems implemented by global governance practices. The vocabulary of (global) governance has become a serious contender to imagine world order in the post cold war world. Using different strategies of critique, the contributors argue that global governance denotes a political vocabulary where acts of definition themselves are political moves.

Die Arbeit ist ein weiterer Beitrag unseres Institutes zur Anwendung der Plastizittstheorie fur die Bestimmung des Tragwiderstandes von Stahlbetontragern unter Biegung. Schub und Tor- sion. Neben der Klarung fundamentaler Fragen zeigt sie auch Losungen fur praktische Probleme auf und behandelt daraus folgende konstruktive Details. Unsere langjahrigen. beharrlichen Forschungen auf diesem Gebiet haben in dieser als Doktor- arbeit verfassten Studie und in fruheren Berichten ihren Niederschiag gefunden. Mit Freude durfen wir feststellen. dass sich daraus eine einheitliche. auf der Plastizittstheorie fundierte Berechnungsmethode zur Bestimmung des Tragwiderstandes von Stahlbetontragern ent- wickelt hat. die sowohl in den Normen als auch in der Praxis zunehmend Anwendung findet. Zurich. Juli 1978 Prof. Dr. B. Thurlimann INHALTSVERZEICHNIS Seite Vorwort 1. EINLEITUNG 1. 1 Zielsetzung und Uebersicht 1. 2 Grundlagen 2 1. 3 GrenzwertsatzD der Plastizitatstheorie [5] 3 K A PIT ELI: FLIESSBEOINGUNG UNO FLIESSGESETZ FUER STAHLBETONSCHEIBEN 4 2. FLIESSBEOINGUNGEN 4 2. 1 Annahmen 4 2. 2 Herleitung 5 2. 3 Statik der einzelnen Fliessregimes 9 3. FLIESSGESETZ UNO KINEMATIK 11 3. 1 Spannungs-Verzerrungs-Beziehungen 12 3. 2 Kinematik der einzelnen Fliessregimes 12 3. 3 Unstetige Geschwindigkeitsfelder 15 4. ERGAENZUNGEN 19 4. 1 Nichtorthogonale Armierung 19 4. 2 Wirklichkeitsnahere zweiaxiale Betonfestigkeit 22 5. EXPERIMENTELLE ERGEBNISSE 25 K A PIT E L II: BALKENTHEORIE 27 6. BALKEN 1M FLIESSREGIME I: FACHWERKMOOELL UNO BALKENTHEORIE 27 6. 1 Parametrische Oarstellung von Fliessflache und Fliessgesetz im Regime I 27 6. 2 Fachwerkmodell 29 6. 3 Balkentheorie 32 6.

Die erheblichen Anstrengungen zur Losung unserer driingendsten soziookono- misch n und okologischen Probleme konnten bisher nicht verhindern, daB Belastung und Verbrauch unserer okologischen Existenzbedingungen zunehmend zum Schwiicheglied der okonomischen und gesellschaftlichen Zielvorstellungen wird. Diese Erscheinungen sind einerseits Symptom eines langfristig sich ver- schiirfenden, auf vielfiiltige Weise vernetzten okologisch-okonomischen Gesamt- problems, andererseits Hinweis auf das Fehlen von Einsichten in eine Fulle grundlegender okologischer Zusammenhiinge. Das bedeutet, daB die Erwar- tungen, die in die O\ Verbesserung von Technologien und Produkten), die Voraussetzung fUr eine gemeinsame Sprache zwischen Okologen, Technologen und Okonomen sind.