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Before the introduction of DDA VP, centrnl diabetes insipidus was
treated by the administration of a more or less purified extract
from bovine or porcine posterior pituitaries, and the prepamtions
were mostly given in the form of nasal snuff. In 1956, the
structure of vasopressin became known and two forms were found,
namely arginine vasopressin (A VP) in humans and most other
species, and lysine vasopressin (L VP) which was found in the pig.
In 1967, Zaornl et al. were the frrst to synthesize
l-desamino-8-D-arginine vasopressin, DDA VP. In comparison with the
compounds which were previously available, DDA VP offered increased
antidiuretic potency and an equally distinct shift of the
antidiuretic to pressor potency rntio. As a result of the
pioneering studies of Cash and Mannucci, numerous publications
appeared in the medical literature of the 80's, widening the fields
of clinical application of the drug. A very important aspect of
this drug is that it can be used as an alternative treatment for
mild factor VllI deficiencies, mild hemophilia A and von
Willebrnnd's disease. These congenital deficiencies are far from
mre and have, up to now, been treated with plasma-derived factor
VIII concentrates; in the countries in which desmopressin has not
been used a consistent proportion of these patients have
seroconverted for HIV 1 and hepatitis.
While the enzyme cascade that allows coagulation is well known
physiologically, its elegant practical examples are vividly
demonstrable in the clinical application of blood and components
for the treatment of bleeding problems in surgery, trauma or in
congenital deficiency in patients. This volume provides the
fundamental and recent understanding relating to coagulation
pathways, recombinant technology and other methods for coagulation
factor production, up to date laboratory assay, preservation of
cellular and plasma components, and their clinical use in surgery
and medicine, including the immuno response to repeated challenge
to contaminating protein in coagulation factor concentrates. The
interrelated but multi-disciplinary chapters have been integrated
in four sections: Principles and Fundamentals: Mechanism of
thrombin formation; structure -- function relationship of
coagulation proteins, role of calcium and anticoagulant: blood
collection on haemostatic potential of plasma proteins and
platelets; Factor VIII yields from anticoagulant exchanged plasma.
Preservation Aspects: Platelet function preservation, platelet
interaction with vessel wall; trends in the use of coagulation
factor concentrate; immuno purification of Factor VIII; structural
and fundamental properties of recombinant coagulation factors.
Laboratory Aspects: Platelets counting and function testing;
platelet crossmatch predictive value; clinical efficacy of platelet
concentrate; protein C and protein S; principle of coagulation
factor assay; standardisation of clotting factor assays; clinical
efficacy of clotting factor concentrates. Clinical Consequences
Edited by two leading orthopedic surgeons who are specialists in
the treatment of hemophilia, Orthopedic Surgery in Patients with
Hemophilia shows all the surgical techniques needed for surgical
treatment of musculoskeletal complications of hemophilia. A
practical guide, designed for use on the ward or in the office,
this book draws on the experience of numerous specialists
worldwide, from developed and developing countries. As well as
orthopedic surgery, it also covers research, hematology, and
rehabilitation. Although of primary interest to the orthopedic
surgeon, rheumatologist, and physiotherapist, this book will also
be relevant to the hematologist responsible for the care of the
hemophiliac patient.
Edited by two leading orthopedic surgeons who are specialists in
the treatment of hemophilia, Orthopedic Surgery in Patients with
Hemophilia shows all the surgical techniques needed for surgical
treatment of musculoskeletal complications of hemophilia. A
practical guide, designed for use on the ward or in the office,
this book draws on the experience of numerous specialists
worldwide, from developed and developing countries. As well as
orthopedic surgery, it also covers research, hematology, and
rehabilitation. Although of primary interest to the orthopedic
surgeon, rheumatologist, and physiotherapist, this book will also
be relevant to the hematologist responsible for the care of the
hemophiliac patient. Written for: Orthopedic surgeons,
hematologists, physiotherapists, rheumatologists
With great pleasure I welcome you to the City of Groningen. In more
than one way there is cause for celebration. Today marks the third
lustrum of the annual international sympo sium on blood
transfusion, organized by the Rode Kruis Bloedbank
Groningen-Drenthe. In my opinion it has been a remarkable
initiative of the Bloedbank, to start organizing a scientific
conference, as it did, in 1976. It meant, among others, that in
case of success the initiative would grow to be an annual item on
the international congress calen der. It also meant that a possible
third lustrum would coincide with the celebration of the 950th
anniversary of the City of Groningen. I am happy to note that the
initiative has been successful: over the past fourteen years the
Rode Kruis Bloedbank Groningen-Drenthe has succeeded in organizing
an annual symposium on blood transfusion, with a different theme
each year, and with an average attendance of 250 participants from
some 26 countries world-wide. The platform created with the special
formula of the symposium, for science and industry, has been well
balanced and beneficial to both. Mr. Chairman, ladies and
gentlemen, I like to compliment the organizers with the success
that they have attained. Allow me to men tion the name of just one
person, in whom I like to thank everyone who has been involved in
creating the annual Bloedbank-symposia: my warm congratulations to
Dr. Smit Sibinga and his staff."
Hemostatis and Desmopressin: Molecular Mechanisms of Cellular
Responses to DDAVP; S. Hashemi, et al. Pharmacology and
Pharmacodynamics of Desmopressin: Toxicity of Desmopressin and
Related Peptides; L.B. Kinter, et al. Desmopressin in Renal
Disease: Control of Bleeding in Uremic Patients; Y. Sultan.
Desmopressin and Platelets: Desmopressin in the Treatment of
Congenital and Acquired Defects of Platelet Function; M. Cattaneo,
P.M. Mannucci. Desmopressin and Surgery: Desmopressin, von
Willenbrand Factor, and Surgery; M. Weinstein. Desmopressin and
Blood Donation: Effects of Desmopressin on Normal Donors in Plasma
Exchange Donations; R.J. Sassetti, B.C. McLeod. Clinical
Applications of Desmopressin in Hemophilia and von Willenbrand's
Disease: Intravenous and Subcutaneous Desmopressin; M. Kohler, G.
Mariani. SideEffects and Adverse Reactions of Desmopressin: DDAVP
and Tachyphylaxis in Healthy Subjects; V. Vicente, et al.
Recapitulation: General Recapitulation and Search for a Consensus;
P.M. Mannucci, et al. 33 additional articles. Index.
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