Hydrophobic character, logP is a physico-chemical property of solute. Knowledge of this hydrophobic character plays an important role to decide the solutes' ability to interface with biochemical systems. It is the measure of the ease with which drug penetrate membranes and bind to lipophilic surface. N-arylbenzohydroxamic acids is drug like molecules it act as anticancer, antiviral, antibacterial etc. and their hydrophobic nature play important role in drug development.

N-Arylhydroxamic acids are drug like molecules. Biological activity always depends upon physico-chemical property namely lipophilicity, which has direct impact on the potency of the molecule. Partition coefficient is a measure of how well a substance partitions between a lipid and water.The partition coefficient has a strong influence on ADME properties of molecules. Both of these parameters are important factor in QSAR.

The aqueous solubility of drugs plays a key role in pharmaceutical, environmental and biological processes. It is an important factor in the ADMET (absorption, distribution, metabolism, elimination and toxicity) research. Since the experimental determination of water solubility is time-consuming therefore, reliable computational predictions are used for the pre-selection of acceptable drug like compounds. The Partial Least Squares (PLS) regression is a statistical method that bears some relation to principal components regression. PLS finds a linear regression model by projecting the predicted variables and the observable variables to a new space. In the present study, PLS regression is employed to model quantitative structure-property relationship (QSPR) for the aqueous solubility of 24 drug like molecules, N-arylhydroxamic acids by applying 15 physico-chemical properties as molecular descriptors. The prediction results are acceptable.

Antioxidants are substances which are able to prevent the oxidative damage by scavenging free radicals created in the body during standard metabolic functions. Free radicals are responsible for ageing process, cancer and atherosclerosis. Majority of lives on earth require oxygen for their existence. Oxygen is a highly reactive molecule that damages living organisms by generating reactive oxygens species, ROS. Antioxidants either prevent these ROS from being formed or remove them before they damage vital components of the cell. On the other hand, ROS are responsible for useful cellular function like redox signalling. Antioxidants help to counterbalance ROS generated in the cell. N-Arylhydroxamic acids are recognised as potent anti-breast cancer agents therefore, antioxidant activity of PBHA, the parent compound of this series is first time derived and presented.