Antioxidants are substances which are able to prevent the oxidative
damage by scavenging free radicals created in the body during
standard metabolic functions. Free radicals are responsible for
ageing process, cancer and atherosclerosis. Majority of lives on
earth require oxygen for their existence. Oxygen is a highly
reactive molecule that damages living organisms by generating
reactive oxygens species, ROS. Antioxidants either prevent these
ROS from being formed or remove them before they damage vital
components of the cell. On the other hand, ROS are responsible for
useful cellular function like redox signalling. Antioxidants help
to counterbalance ROS generated in the cell. N-Arylhydroxamic acids
are recognised as potent anti-breast cancer agents therefore,
antioxidant activity of PBHA, the parent compound of this series is
first time derived and presented.
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