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Showing 1 - 5 of 5 matches in All Departments

Revival: The FOS and JUN Families of Transcription Factors (1994) (Paperback): Peter Herrlich Revival: The FOS and JUN Families of Transcription Factors (1994) (Paperback)
Peter Herrlich; Contributions by Alfred Nordheim, Axel Schonthal, James R. Feramisco, Meinrad Busslinger, …
R1,752 Discovery Miles 17 520 Ships in 12 - 17 working days

This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

Revival: The FOS and JUN Families of Transcription Factors (1994) (Hardcover): Peter Herrlich Revival: The FOS and JUN Families of Transcription Factors (1994) (Hardcover)
Peter Herrlich; Contributions by Alfred Nordheim, Axel Schonthal, James R. Feramisco, Meinrad Busslinger, …
R6,551 Discovery Miles 65 510 Ships in 12 - 17 working days

This book introduces and analyzes the crucial role of AP-1 in cell growth, proliferation, differentiation, and apoptosis. AP-1 is the endpoint of several pathways of signal transduction, including one that triggers cancerous growth. The control of its activity is an issue of basic science, cancer therapy, and other diseases. The chapters provide multiple viewpoints of the emerging data on AP-1, including its role as a factor regulating genes involved in the metastatic properties of cancer, as a factor that interacts with viral gene products, and as a part of the mechanism by which steroid and retinoic acid receptors function as anti-inflammatory proteins.

A Time for Metabolism and Hormones (Paperback, Softcover reprint of the original 1st ed. 2016): Paolo Sassone-Corsi, Yves... A Time for Metabolism and Hormones (Paperback, Softcover reprint of the original 1st ed. 2016)
Paolo Sassone-Corsi, Yves Christen
R1,557 Discovery Miles 15 570 Ships in 10 - 15 working days

Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

Epigenetics, Brain and Behavior (Paperback): Paolo Sassone-Corsi, Yves Christen Epigenetics, Brain and Behavior (Paperback)
Paolo Sassone-Corsi, Yves Christen
R4,448 Discovery Miles 44 480 Ships in 10 - 15 working days

Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

Germ Cells (Hardcover, New): Paolo Sassone-Corsi, Margaret T. Fuller, Robert E. Braun Germ Cells (Hardcover, New)
Paolo Sassone-Corsi, Margaret T. Fuller, Robert E. Braun
R2,808 Discovery Miles 28 080 Ships in 12 - 17 working days

In sexually reproducing organisms, germ cells give rise to gametes and serve as the link between generations. A key event during germ cell development is the decision to leave mitosis and enter meiosis, leading to the formation of mature eggs and sperm. Germ cell development involves unique gene expression programs and the establishment of epigenetic marks that ensure success during fertilization and embryo development. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the biology of germ cells in metazoans. The contributors describe the undifferentiated state of germline stem cells, the triggers for meiotic entry, and the transcriptional and post transcriptional controls during spermatogenesis and oogenesis that lead to the formation of mature gametes. The expression of sex linked genes and the establishment of genomic imprinting in the germline are also covered. This volume, which includes discussions of gamete recognition proteins, egg activation, and genetic reprogramming following nuclear transfer, is an indispensable reference for cell, molecular, and developmental biologists and anyone wishing to understand the implications of germ cell biology for reproductive technologies.

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