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This book introduces and analyzes the crucial role of AP-1 in cell
growth, proliferation, differentiation, and apoptosis. AP-1 is the
endpoint of several pathways of signal transduction, including one
that triggers cancerous growth. The control of its activity is an
issue of basic science, cancer therapy, and other diseases. The
chapters provide multiple viewpoints of the emerging data on AP-1,
including its role as a factor regulating genes involved in the
metastatic properties of cancer, as a factor that interacts with
viral gene products, and as a part of the mechanism by which
steroid and retinoic acid receptors function as anti-inflammatory
proteins.
This book introduces and analyzes the crucial role of AP-1 in cell
growth, proliferation, differentiation, and apoptosis. AP-1 is the
endpoint of several pathways of signal transduction, including one
that triggers cancerous growth. The control of its activity is an
issue of basic science, cancer therapy, and other diseases. The
chapters provide multiple viewpoints of the emerging data on AP-1,
including its role as a factor regulating genes involved in the
metastatic properties of cancer, as a factor that interacts with
viral gene products, and as a part of the mechanism by which
steroid and retinoic acid receptors function as anti-inflammatory
proteins.
Recent years have seen spectacular advances in the field of
circadian biology. These have attracted the interest of researchers
in many fields, including endocrinology, neurosciences, cancer, and
behavior. By integrating a circadian view within the fields of
endocrinology and metabolism, researchers will be able to reveal
many, yet-unsuspected aspects of how organisms cope with changes in
the environment and subsequent control of homeostasis. This field
is opening new avenues in our understanding of metabolism and
endocrinology. A panel of the most distinguished investigators in
the field gathered together to discuss the present state and the
future of the field. The editors trust that this volume will be of
use to those colleagues who will be picking up the challenge to
unravel how the circadian clock can be targeted for the future
development of specific pharmacological strategies toward a number
of pathologies.
Recent years have seen spectacular advances in the filed of
epigenetics. These have attracted the interest of researchers in
many fields and evidence connecting epigentic regulation to brain
functions has been accumulationg. Neurons daily convert a variety
of external stimuli into rapid or long-lasting changes in gene
expression. A variety of studies have centered on the molcular
mechanisms implicated in epigentic control and how these may operte
in concert. It will be critical to unravel how specifity is
achieved. The focus of this volume is on critical epigenetic
regulation and chromatin remodeling events that occur in the
nervous system and on the presumed mechanisms that operate within
neurons to translate them into long-lasting neuronal responses.
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Germ Cells (Hardcover, New)
Paolo Sassone-Corsi, Margaret T. Fuller, Robert E. Braun
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R2,808
Discovery Miles 28 080
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Ships in 12 - 17 working days
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In sexually reproducing organisms, germ cells give rise to gametes
and serve as the link between generations. A key event during germ
cell development is the decision to leave mitosis and enter
meiosis, leading to the formation of mature eggs and sperm. Germ
cell development involves unique gene expression programs and the
establishment of epigenetic marks that ensure success during
fertilization and embryo development. Written and edited by experts
in the field, this collection from Cold Spring Harbor Perspectives
in Biology reviews the biology of germ cells in metazoans. The
contributors describe the undifferentiated state of germline stem
cells, the triggers for meiotic entry, and the transcriptional and
post transcriptional controls during spermatogenesis and oogenesis
that lead to the formation of mature gametes. The expression of sex
linked genes and the establishment of genomic imprinting in the
germline are also covered. This volume, which includes discussions
of gamete recognition proteins, egg activation, and genetic
reprogramming following nuclear transfer, is an indispensable
reference for cell, molecular, and developmental biologists and
anyone wishing to understand the implications of germ cell biology
for reproductive technologies.
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