The purpose of this book is to integrate the most re- butions and support of my colleagues and friends cent advances in the diagnosis and treatment of pedi- at The University of Texas Southwestern Medical atric bone and soft tissue sarcomas. The book is di- School,St. Jude Children's Research Hospital,and the vided into two major sections,the ?rst of which pres- Hospital for Sick Children in Toronto. In particular,I ents salient concepts in epidemiology,the impact of would like to thank Drs. George Buchanan, Charles novel tools in imaging and molecular biology,and the Pratt,William Crist, David Parham, Jim Anderson, underlying principles for continued drug develop- and Larry Kun for their friendship,mentorship,and ment. In the second section,the book embarks on an wisdom. Their teachings will continue to be an e- up-to-date survey of the diagnosis and treatment of less source of passion and inspiration. It is my wish each speci?c disease,with particular emphasis on the that this book will provide answers, guidance and need for an integrative, multidisciplinary approach hope to medical professionals, children, and their to diagnosis and treatment. families. I am indebted to my colleagues and collaborators who have contributed their ideas, time, and kno- edge to this project. I am also grateful for the contri- Alberto Pappo,MD IX Contents 1 Epidemiology of Bone 3 Diagnostic Imaging of Pediatric Bone and Soft Tissue Sarcomas and Soft Tissue Sarcomas Logan G. Spector,Julie A. Ross, Thomas D. Henry,Mary E. McCarville, Rajaram Nagarajan Fredric A.

The purpose of this book is to integrate the most re- butions and support of my colleagues and friends cent advances in the diagnosis and treatment of pedi- at The University of Texas Southwestern Medical atric bone and soft tissue sarcomas. The book is di- School,St. Jude Children's Research Hospital,and the vided into two major sections,the ?rst of which pres- Hospital for Sick Children in Toronto. In particular,I ents salient concepts in epidemiology,the impact of would like to thank Drs. George Buchanan, Charles novel tools in imaging and molecular biology,and the Pratt,William Crist, David Parham, Jim Anderson, underlying principles for continued drug develop- and Larry Kun for their friendship,mentorship,and ment. In the second section,the book embarks on an wisdom. Their teachings will continue to be an e- up-to-date survey of the diagnosis and treatment of less source of passion and inspiration. It is my wish each speci?c disease,with particular emphasis on the that this book will provide answers, guidance and need for an integrative, multidisciplinary approach hope to medical professionals, children, and their to diagnosis and treatment. families. I am indebted to my colleagues and collaborators who have contributed their ideas, time, and kno- edge to this project. I am also grateful for the contri- Alberto Pappo,MD IX Contents 1 Epidemiology of Bone 3 Diagnostic Imaging of Pediatric Bone and Soft Tissue Sarcomas and Soft Tissue Sarcomas Logan G. Spector,Julie A. Ross, Thomas D. Henry,Mary E. McCarville, Rajaram Nagarajan Fredric A.

During the 3rd International Congress on Neoadjuvant Chemotherapy (Paris 1991) a complete symposium was devoted to chemically induced nausea and vomiting and to the value of Ondansetron. This book comprises original articles dealing with the different topics discussed during this session. It provides fuller information on current practice in anti-emetic treatment during anti-cancerous chemotherapy and sets out the position of a new and important drug, ondansetron, in this pathology. Different international clinical studies made with ondansetron in various types of patients are analysed: specific studies in hematology or in pulmonary disease, evaluation against benzamide-corticoid as a combined reference standard, or further the additive effect of a corticoid combined with ondansetron. One article is devoted to the use of the drug in children. Finally, recent programmes dealing with both the intravenous and the oral use of ondansetron are assessed. The last article deals with the economic evaluation of the use of ondansetron. Thus the reader will findhere a recent and uo-to-date review of the results and possible uses of ondansetron, now the premier member of the class of 5 HT 3 antagonists, in chemically induced nausea and vomiting.

Finalist for the Lambda Literary Award for Debut Fiction! Finalist for the Publishing Triangle Edmund White Award for Debut Fiction! Recalling both the excess of The Wolf of Wall Street, and the drifting narrator of A Single Man, Ioannis Pappos's debut novel is a portrait of privilege, aspiration, and international finance during the wayward course of the American economy between 9/11 and the 2008 Financial collapse, and is filled with surprisingly tender observations about identity, loneliness, and human connection. "I'm homeless, but in First Class." Stathis Rakis abandoned his small Greek village for a more worldly life, first in San Francisco, where the Dot Com Bubble had already burst, and then in Paris, France, where he is pursuing an MBA at an elite business school. After falling helplessly in love with a liberal New England journalist with a good conscience, who comes to campus with some scores to settle, Stathis moves to the United States to begin as a consultant for a company called Command. He spends the very few hours of the day that aren't consumed by work draining the minibar, battling insomnia, and binging on more than room service. Luxury is a given, happiness is not. As the economy recovers and a new bubble expands in a post-9/11 world, Stathis drifts upward, baring witness to the criminal decadence that will become the 2008 financial crisis, as well as his new habits of indulgence-drugs, sex, and insider trading. In a world of insiders--from corporate suits to Hollywood celebutantes-Stathis remains the outsider: too foreign to be one of them, too cynical to turn back.