The purpose of this book is to integrate the most re- butions and
support of my colleagues and friends cent advances in the diagnosis
and treatment of pedi- at The University of Texas Southwestern
Medical atric bone and soft tissue sarcomas. The book is di-
School,St. Jude Children's Research Hospital,and the vided into two
major sections,the ?rst of which pres- Hospital for Sick Children
in Toronto. In particular,I ents salient concepts in
epidemiology,the impact of would like to thank Drs. George
Buchanan, Charles novel tools in imaging and molecular biology,and
the Pratt,William Crist, David Parham, Jim Anderson, underlying
principles for continued drug develop- and Larry Kun for their
friendship,mentorship,and ment. In the second section,the book
embarks on an wisdom. Their teachings will continue to be an e-
up-to-date survey of the diagnosis and treatment of less source of
passion and inspiration. It is my wish each speci?c disease,with
particular emphasis on the that this book will provide answers,
guidance and need for an integrative, multidisciplinary approach
hope to medical professionals, children, and their to diagnosis and
treatment. families. I am indebted to my colleagues and
collaborators who have contributed their ideas, time, and kno- edge
to this project. I am also grateful for the contri- Alberto
Pappo,MD IX Contents 1 Epidemiology of Bone 3 Diagnostic Imaging of
Pediatric Bone and Soft Tissue Sarcomas and Soft Tissue Sarcomas
Logan G. Spector,Julie A. Ross, Thomas D. Henry,Mary E. McCarville,
Rajaram Nagarajan Fredric A.
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