Protein hydrolysates, otherwise commonly known as peptones or peptides, are used in a wide variety of products in fermentation and biotechnology industries. The term "peptone" was first introduced in 1880 by Nagelli for growing bacterial cultures. However, later it was discovered that peptones derived from the partial digestion of proteins would furnish organic nitrogen in readily available form. Ever since, p- tones, which are commonly known as protein hydrolysates, have been used not only for growth of microbial cultures, but also as nitrogen source in commercial fermen- tions using animal cells and recombinant microorganisms for the production of value added products such as therapeutic proteins, hormones, vaccines, etc. Today, the characterization, screening and manufacturing of protein hyd- lysates has become more sophisticated, with the introduction of reliable analytical instrumentation, high throughput screening techniques coupled with statistical design approaches, novel enzymes and efficient downstream processing equipment. This has enabled the introduction of custom-built products for specialized appli- tions in diverse fields of fermentation and biotechnology, such as the following. 1. Protein hydrolysates are used as much more than a simple nitrogen source. For example, the productivities of several therapeutic drugs made by animal cells and recombinant microorganisms have been markedly increased by use of p- tein hydrolysates. This is extremely important when capacities are limited. 2. Protein hydrolysates are employed in the manufacturing of vaccines by ferm- tation processes and also used as vaccine stabilizers.

Protein hydrolysates, otherwise commonly known as peptones or peptides, are used in a wide variety of products in fermentation and biotechnology industries. The term "peptone" was first introduced in 1880 by Nagelli for growing bacterial cultures. However, later it was discovered that peptones derived from the partial digestion of proteins would furnish organic nitrogen in readily available form. Ever since, p- tones, which are commonly known as protein hydrolysates, have been used not only for growth of microbial cultures, but also as nitrogen source in commercial fermen- tions using animal cells and recombinant microorganisms for the production of value added products such as therapeutic proteins, hormones, vaccines, etc. Today, the characterization, screening and manufacturing of protein hyd- lysates has become more sophisticated, with the introduction of reliable analytical instrumentation, high throughput screening techniques coupled with statistical design approaches, novel enzymes and efficient downstream processing equipment. This has enabled the introduction of custom-built products for specialized appli- tions in diverse fields of fermentation and biotechnology, such as the following. 1. Protein hydrolysates are used as much more than a simple nitrogen source. For example, the productivities of several therapeutic drugs made by animal cells and recombinant microorganisms have been markedly increased by use of p- tein hydrolysates. This is extremely important when capacities are limited. 2. Protein hydrolysates are employed in the manufacturing of vaccines by ferm- tation processes and also used as vaccine stabilizers.

Explore architectural approaches to building Data Lakes that ingest, index, manage, and analyze massive amounts of data using Big Data technologies About This Book * Comprehend the intricacies of architecting a Data Lake and build a data strategy around your current data architecture * Efficiently manage vast amounts of data and deliver it to multiple applications and systems with a high degree of performance and scalability * Packed with industry best practices and use-case scenarios to get you up-and-running Who This Book Is For This book is for architects and senior managers who are responsible for building a strategy around their current data architecture, helping them identify the need for a Data Lake implementation in an enterprise context. The reader will need a good knowledge of master data management and information lifecycle management, and experience of Big Data technologies. What You Will Learn * Identify the need for a Data Lake in your enterprise context and learn to architect a Data Lake * Learn to build various tiers of a Data Lake, such as data intake, management, consumption, and governance, with a focus on practical implementation scenarios * Find out the key considerations to be taken into account while building each tier of the Data Lake * Understand Hadoop-oriented data transfer mechanism to ingest data in batch, micro-batch, and real-time modes * Explore various data integration needs and learn how to perform data enrichment and data transformations using Big Data technologies * Enable data discovery on the Data Lake to allow users to discover the data * Discover how data is packaged and provisioned for consumption * Comprehend the importance of including data governance disciplines while building a Data Lake In Detail A Data Lake is a highly scalable platform for storing huge volumes of multistructured data from disparate sources with centralized data management services. This book explores the potential of Data Lakes and explores architectural approaches to building data lakes that ingest, index, manage, and analyze massive amounts of data using batch and real-time processing frameworks. It guides you on how to go about building a Data Lake that is managed by Hadoop and accessed as required by other Big Data applications. This book will guide readers (using best practices) in developing Data Lake's capabilities. It will focus on architect data governance, security, data quality, data lineage tracking, metadata management, and semantic data tagging. By the end of this book, you will have a good understanding of building a Data Lake for Big Data. Style and approach Data Lake Development with Big Data provides architectural approaches to building a Data Lake. It follows a use case-based approach where practical implementation scenarios of each key component are explained. It also helps you understand how these use cases are implemented in a Data Lake. The chapters are organized in a way that mimics the sequential data flow evidenced in a Data Lake.

A comprehensive practical guide that walks you through the multiple stages of data management in enterprise and gives you numerous design patterns with appropriate code examples to solve frequent problems in each of these stages. The chapters are organized to mimick the sequential data flow evidenced in Analytics platforms, but they can also be read independently to solve a particular group of problems in the Big Data life cycle. If you are an experienced developer who is already familiar with Pig and is looking for a use case standpoint where they can relate to the problems of data ingestion, profiling, cleansing, transforming, and egressing data encountered in the enterprises. Knowledge of Hadoop and Pig is necessary for readers to grasp the intricacies of Pig design patterns better.

Type 2 diabetes is a growing problem for the developed and developing countries and it is a burden on healthcare systems as well as individuals. Nutraceuticals, Glycemic Health and Type 2 Diabetes primarily focuses on the nutraceuticals that assist in preventing and managing prediabetes and type 2 diabetes. The book gives an overview of glycemic health and highlights the use of novel and upcoming nutraceutical ingredients such as bioactive peptides, traditional herbs from India and Mexico, resistant starches, cinnamon, chromium III and others. After the successful commercial application of bioactive peptides as nutraceutical ingredients in the management of blood pressure, companies are now focusing on peptides for the prevention and management of type 2 diabetes. Resistant starches in the clinical studies have demonstrated to reduce the glycemic and insulin response and increasing insulin sensitivity. These and other nutraceuticals that are supported by scientific and clinical studies are highlighted. The editors and contributors are experts in their respective fields and are largely from the university, industry and government. Nutraceuticals, Glycemic Health and Type 2 Diabetes will be useful as a standard reference book for all those concerned with the role of nutraceuticals and glycemia in the prevention and control of type 2 diabetes.