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Protein Hydrolysates in Biotechnology (Paperback, 2010 ed.)
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Discovery Miles 28 330
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Protein Hydrolysates in Biotechnology (Paperback, 2010 ed.)
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Protein hydrolysates, otherwise commonly known as peptones or
peptides, are used in a wide variety of products in fermentation
and biotechnology industries. The term "peptone" was first
introduced in 1880 by Nagelli for growing bacterial cultures.
However, later it was discovered that peptones derived from the
partial digestion of proteins would furnish organic nitrogen in
readily available form. Ever since, p- tones, which are commonly
known as protein hydrolysates, have been used not only for growth
of microbial cultures, but also as nitrogen source in commercial
fermen- tions using animal cells and recombinant microorganisms for
the production of value added products such as therapeutic
proteins, hormones, vaccines, etc. Today, the characterization,
screening and manufacturing of protein hyd- lysates has become more
sophisticated, with the introduction of reliable analytical
instrumentation, high throughput screening techniques coupled with
statistical design approaches, novel enzymes and efficient
downstream processing equipment. This has enabled the introduction
of custom-built products for specialized appli- tions in diverse
fields of fermentation and biotechnology, such as the following. 1.
Protein hydrolysates are used as much more than a simple nitrogen
source. For example, the productivities of several therapeutic
drugs made by animal cells and recombinant microorganisms have been
markedly increased by use of p- tein hydrolysates. This is
extremely important when capacities are limited. 2. Protein
hydrolysates are employed in the manufacturing of vaccines by ferm-
tation processes and also used as vaccine stabilizers.
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