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Road traffic injuries account for 2.1% of global mortality. The
developing countries bear a large share of burden and account for
about 85% of the deaths as a result of road traffic crashes. 2]
India accounts for about 10% of road accident fatalities worldwide.
3] Road accident contributed 30.2% to all kind of natural and
unnatural accidental deaths during 2005 4]. According to the
Institute of Road Traffic Education (2006) New Delhi, out of the
estimated 1.4 million serious road accidents/ collisions occurring
annually in India, hardly 0.4 million are recorded. 5] This
indicates that the surveillance system for vehicular accidents is
not well established in India. Epidemiological data on road traffic
accidents in India have been reported but there is no proper
correlation with head injury. The study correlating head injury
with road traffic accidents in Delhi was done in 1979 since then
there have been significant social and demographic changes
including changes in life style, population and number of vehicles.
Continuous growth in number of motor vehicles, increase in
population and poor access to health care are some of the important
factors in fatalities.
Liposomes as well as formulations based on drug-lipid complexes
have been extensively investigated for the delivery of a wide range
of pharmaceutical compounds. Commercial licensing of liposomal
dispersions for parenteral and topical use in humans has been
fairly recent and has occurred as a result of interdisciplinary
scientific advances in surface chemistry, membrane biophysics, and
molecular pharmacology. These developments were supported by
pioneering contributions from scientists in the fields of molecular
pharmaceutics, drug delivery, and chemical engineering. Thus, since
their original simplistic use as vesicular models for studying
membrane properties and transport, liposomal systems have evolved
into complex yet elegant assemblies for drug delivery. Liposomes
are now being developed with specific therapeutic roles for tissue
and cellular targeting and have been skillfully manipulated to
achieve desired clinical outcomes by altering in vivo drug
biodistribution and disposition. Liposomes are microscopic vesicles
composed of one or more lipid bilayers arranged in concentric
fashion enclosing an equal number of aqueous compartments.
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