Road traffic injuries account for 2.1% of global mortality. The developing countries bear a large share of burden and account for about 85% of the deaths as a result of road traffic crashes. 2] India accounts for about 10% of road accident fatalities worldwide. 3] Road accident contributed 30.2% to all kind of natural and unnatural accidental deaths during 2005 4]. According to the Institute of Road Traffic Education (2006) New Delhi, out of the estimated 1.4 million serious road accidents/ collisions occurring annually in India, hardly 0.4 million are recorded. 5] This indicates that the surveillance system for vehicular accidents is not well established in India. Epidemiological data on road traffic accidents in India have been reported but there is no proper correlation with head injury. The study correlating head injury with road traffic accidents in Delhi was done in 1979 since then there have been significant social and demographic changes including changes in life style, population and number of vehicles. Continuous growth in number of motor vehicles, increase in population and poor access to health care are some of the important factors in fatalities.

Liposomes as well as formulations based on drug-lipid complexes have been extensively investigated for the delivery of a wide range of pharmaceutical compounds. Commercial licensing of liposomal dispersions for parenteral and topical use in humans has been fairly recent and has occurred as a result of interdisciplinary scientific advances in surface chemistry, membrane biophysics, and molecular pharmacology. These developments were supported by pioneering contributions from scientists in the fields of molecular pharmaceutics, drug delivery, and chemical engineering. Thus, since their original simplistic use as vesicular models for studying membrane properties and transport, liposomal systems have evolved into complex yet elegant assemblies for drug delivery. Liposomes are now being developed with specific therapeutic roles for tissue and cellular targeting and have been skillfully manipulated to achieve desired clinical outcomes by altering in vivo drug biodistribution and disposition. Liposomes are microscopic vesicles composed of one or more lipid bilayers arranged in concentric fashion enclosing an equal number of aqueous compartments.