The existence of CNS viral reservoirs is the main cause of recurrence of HIV infection after medication is withdrawn. This problem remains unsolved because of poor CNS penetration with the existing anti retroviral drugs. To meet the demand of crossing the blood-brain barrier (BBB) the compound should have polar surface area (PSA). PSA is defined as the surface area occupied by oxygen and nitrogen atoms and hydrogen atoms attached to these atoms. With this aspect in view, we calculated the PSA values of various substituent on the aryl rings in our aimed compounds and they were found within the prescribed limits so we proceeded with the synthesis of the compounds.

Arthritis is the inflammation of a joint, which can include infiltration of inflammatory cells, synovial hyperplasia, bone erosion and new bone formation, narrowing of the joint space. Arthritis was induced in knee joint cavity of the right hind leg by intra-articular injection of 0.1ml of 1% carrageenan in all groups except control group. Animals are divided into five different groups such as Normal control, arthritis control, Standard A (MOOV) treated group, Standard B (RUMALAYA) treated group and test drug treated group. Catalase activity, Alkaline Phosphatase, MDA and Uric acid were significantly (p