This book explains the fundamental characteristics and biofunctionality of Alzheimer’s Disease drug targets and provides up-to-date information on the full range of their biomedical applications. An introductory section gives an overview of the recent developments related to drug targets identified and studied related to Alzheimer’s Disease and key developments from preclinical and clinical studies focusing on various molecular targets related to AD and dementia by subject experts all around the globe. Here, individual chapters address the progress and perspectives in human and non-human research, role of various biomarkers as an overview, advanced gene therapy, and novel compounds for therapeutic targets for Alzheimer’s disease. The book will be essential reading for graduate students, scientists, and engineers in any of the biomedical research fields in which efforts are being made to utilize novel drug targets and develop effective strategies for new drug targeting and delivery in Alzheimer’s disease treatment.

Analyzing data sets has continued to be an invaluable application for numerous industries. By combining different algorithms, technologies, and systems used to extract information from data and solve complex problems, various sectors have reached new heights and have changed our world for the better. The Handbook of Research on Engineering, Business, and Healthcare Applications of Data Science and Analytics is a collection of innovative research on the methods and applications of data analytics. While highlighting topics including artificial intelligence, data security, and information systems, this book is ideally designed for researchers, data analysts, data scientists, healthcare administrators, executives, managers, engineers, IT consultants, academicians, and students interested in the potential of data application technologies.

This book offers valuable insights into the principles, mechanisms of action and applications of traditional and novel enzymes involved in the degradation of wastes. Enzymes are biological catalysts that play an important role in various biochemical reactions. The generation of value-added products by means of these biological processes is also discussed. This book covers the use of in silico and computational methods in understanding the biodegradation processes, and reveals the importance of enzymes in various biochemical reactions and kinetics. The book's target audience includes undergraduate and graduate students, faculty members at colleges and universities, research students, scientists and industry professionals.

This book discusses the sensitivity, selectivity, and response times of different sensor materials and their potential application in the design of portable sensor systems for monitoring water pollutants and remediation systems. Beginning with an overview on water pollutants and analytical methods for their detection, the book then moves on to describing the advances in sensor materials research, and the scope for their use in different types of sensors. The book lays emphasis on techniques such as colorimetric, fluorescence, electrochemical, and biological sensing of conventional and emerging pollutants. This book will serve as a handy guide for students, researchers, and professional engineers working in the field of sensor systems for monitoring water pollutants to address various challenges.

Changes in the planet's climate in recent years have led to significant impacts on natural resources and ecosystems. New strategies must be adopted in order to support the protection and continued development of numerous natural resources. Reconsidering the Impact of Climate Change on Global Water Supply, Use, and Management is a pivotal reference source for the latest scholarly material on the relationship between global climate changes and the planet's water ecosystems. Highlighting relevant environmental, social, and economic issues, this book is ideally designed for academics, researchers, policy makers, students, and practitioners interested in the impacts of climate change on global water resources.

This book covers important concepts and applications of contemporary physics. The book emphasizes logical development of the subject and attempts to maintain rigor in the analytical discussions. The text has been presented in a concise and lucid manner. A modern description of properties and interaction of particle is given along with discussions on topics such as cosmology, laser and applications. The concepts are illustrated by numerous worked examples. Selected problems given at the end of each chapter help students to evaluate their skills. The book with its simple style, comprehensive and up-to-date coverage is highly useful for physics students. The detailed coverage and pedagogical tools make this an ideal book also for the engineering students studying core courses in physics.

Urticaria, commonly known as ‘hives’, is a skin rash which can have allergic and non-allergic causes. This handbook is an initiative of the Global Allergy and Asthma European Network (GA2LEN) Urticaria Centers of Reference and Excellence (UCARE). Divided into 22 sections, the text begins with an overview of urticaria, its classification, and aetiopathogenesis. The next chapters describe different types of urticaria, diagnostic measures, and therapeutic management. The final sections examine urticaria in children, in the elderly, in pregnancy and lactation, and in kidney, liver and cardiac disease. A separate chapter covers patient education material. Authored by renowned worldwide experts, the text is further enhanced by clinical images, tables and figures to assist learning.

This book is a comprehensive guide to clinical anaesthesia for practitioners and trainees. Divided into eleven sections, the text begins with a general overview, followed by discussion on anaesthesia delivery systems, monitoring, and equipment. A complete section is dedicated to different drugs used in anaesthesia. The next section covers anaesthesia for different types of surgeries in various body systems. The remaining chapters detail more subspecialty-specific anaesthesia including cardiac, obstetric, neuro, paediatric, transplant, and regional. The book concludes with a section on postoperative care. Authored by highly experienced experts in the field, the text is further enhanced by illustrations and figures to assist learning. Key points Comprehensive guide to clinical anaesthesia for practitioners and trainees Covers numerous types of anaesthesia for different surgeries and body systems Includes sections on pharmacology and postoperative care Highly experienced, expert author team

Signal and Acoustic Modeling for Speech and Communication Disorders demonstrates how speech signal processing and acoustic modeling can be instrumental in early detection and successful intervention with speech deficits resulting from Parkinson's disease, Autism Spectrum disorder, cleft palate, intellectual disabilities, and neuro-motor impairments. Utilizing some of the most advanced methods in signal and acoustic modeling, this eminent group of contributors show how such technologies can inure to the benefit of healthcare and to society writ large. Paradoxically, what most of us take for granted still remains a Sisyphean battle for those with speech and language disorders, who struggle every day to make themselves heard and understood. The purpose of this book is to stimulate a vibrant discussion among speech scientists, system designers, and practitioners on how to best marshal the latest advances in signal and acoustic modeling to address some of the most challenging speech and communication disorders affecting a wide variety of patient populations across the world.

The book explores new ways to reconstruct and enhance speech that is compromised by various neuro-motor disorders - collectively known as "dysarthria." The authors address some of the extant lacunae in speech research of dysarthric conditions: they show how new methods can improve speaker recognition when speech is impaired due to developmental or acquired pathologies; they present a novel multi-dimensional approach to help the speech system both assess dysarthric speech and to perform intelligibility improvement of the impaired speech; they display well-performing software solutions for developmental and acquired speech impairments, and for vocal injuries; and they examine non-acoustic signals and muted nonverbal sounds in relation to audible speech conversion.

This book provides a concise overview of the Apocynaceae plant family, focusing on its morphology, diversity, ethnopharmacology, phytochemistry, and biological activities. It explores biotechnological advances in large-scale production of therapeutic bioactive compounds and conservation efforts using plant tissue culture.   The family Apocynaceae is one of the largest and important families in angiosperm, with several members having medicinal properties used to treat various ailments. Most of them are consumed as food by tribal people, while a few plants are used as a source of poison, insecticides, gum, and many other important products. Members of this family are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones and hydrocarbons. Other compounds such as sterols, lignans, and sugars have also been systematically studied. Extracts and isolated compounds from Apocynaceae members exhibit antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities. Notable plants like Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata have been extensively researched. The family presents a diverse range of bioactive compounds with medicinal and pharmacological properties, holding promise for future applications.   The book also covers endophytic microorganisms with their diversity, biological activities in Apocynaceae plants. It also highlights the role of endophytes in conservation of Apocynaceae plants. By identifying existing knowledge gaps, it aims to inspire further research in the field, making it a valuable resource for students and researchers in Life Sciences, agriculture, medicine, and pharmaceutical sciences.