Environmental endocrine disruptors have been at the heart of discussions about chemicals and their effects on fertility, but the focus has been on organic compounds and the role of metals has been largely overlooked - until now. Taking an organ-system-based approach, Metals, Fertility, and Reproductive Toxicity examines the effects of metals found in the everyday environment on fertility rates in humans and animal populations. This volume summarizes and evaluates the literature in the area of metal effects on fertility and reproduction in humans, laboratory animals, and wildlife. International experts have contributed chapters that explore how the ovary, testes, uterine system, and neuroendocrine system, among others, respond to metal exposure. Reviewing both current knowledge and cutting edge data, the chapters focus on either a particular metal or a particular population. A massive amount of data on this subject has been generated, summarized, and reviewed over the years. While there are many books available on metals toxicity and on reproductive toxicity, no current book explores both in the same volume. Culling information from throughout the literature, Metals, Fertility, and Reproductive Toxicity supplies an in-depth look at the role of metals in endocrine disruption and the spectrum of mechanisms involving metals that can influence reproduction.

Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be better understood. In recent years, research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles is gaining greater appreciation. Ovarian Toxicology, Second Edition represents a compilation of chapters prepared by researchers who have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. The second edition substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition. Topics include: Ovarian physiology and the metabolism of xenobiotics The effect of pesticides, heavy metals, phthalates, BPA, and cigarette smoking on the ovaries Ovarian cancer, including endocrine effects and new perspectives on chemoresistance Epidemiology and human health risk assessment for environmental chemicals and pharmaceuticals The first book to focus specifically on ovarian toxicology, this resource is ideal for scientists in academia, regulatory agencies, and industry who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.

Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be better understood. In recent years, research into chemicals that have the potential to cause early menopause by destroying pre-antral ovarian follicles is gaining greater appreciation. Ovarian Toxicology, Second Edition represents a compilation of chapters prepared by researchers who have substantially contributed to our understanding of the impact of xenobiotics and environmental factors on ovarian function. The second edition substantially updates newly investigated ovotoxicants as well as improved mechanistic insights that have emerged since the first edition. Topics include: Ovarian physiology and the metabolism of xenobiotics The effect of pesticides, heavy metals, phthalates, BPA, and cigarette smoking on the ovaries Ovarian cancer, including endocrine effects and new perspectives on chemoresistance Epidemiology and human health risk assessment for environmental chemicals and pharmaceuticals The first book to focus specifically on ovarian toxicology, this resource is ideal for scientists in academia, regulatory agencies, and industry who would benefit from a survey of the impact of xenobiotic chemicals on ovarian function.